SERT variant | Location | Effect on Function |
---|---|---|
Gly56Ala [49] | N-terminal intracellular tail | ~30% increase in 5-HT uptake; absent upregulation by PKG, p38-MAPK [72, 79] |
Ile425Leu [49] | Transmembrane domain | ~70% increase in 5-HT uptake; increased cell surface expression [79] |
Ile425Val [77] | Transmembrane domain | ~70% increase in 5-HT uptake; increased cell surface expression vs. altered PKG regulation [79, 94] |
Phe465Leu [49] | Transmembrane domain | ~70% increase in 5-HT uptake; increased cell surface expression [79] |
Leu550Val [49] | Transmembrane domain | ~70% increase in 5-HT uptake; increased cell surface expression [79] |
Lys605Asn [49] | C-terminal intracellular tail | ~30% increase in 5-HT uptake [72] |