VBM analysis of white matter volume of 22q11DS subjects vs. controls (cluster significance thresholdp = 0.006) | |||||
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Not controlled for IQ | |||||
White matter volume deficits in 22q11DS subjects | |||||
Cluster size (number of voxels) | Talairach and Tournoux Coordinates | Region | Hemisphere | ||
x | y | z | |||
4218 | 1 | −36 | −11 | Brainstem/cerebellum | Right |
149 | 34 | −19 | −9 | Hippocampus | Right |
77 | −33 | −35 | −2 | Hippocampus | Left |
533 | 28 | −71 | 6 | Middle occipital gyrus/optic radiation and lingual, middle and inferior occipital gyri/cuneus and precuneus | Right |
688 | 8 | −11 | 23 | Body, genu and splenium of corpus callosum | Inter-hemispheric |
489 | −12 | −17 | 52 | Medial frontal gyrus/paracentral lobule | Left |
White matter volume excesses in 22q11DS subjects | |||||
133 | −8 | 28 | −15 | Corpus callosum/cingulum/medial frontal gyrus | Left |
459 | −13 | 5 | 1 | Globus pallidus/anterior limb and genu of internal capsule | Left |
396 | 20 | 1 | 3 | Putamen/anterior limb and genu of internal capsule | Right |
341 | 2 | −13 | 25 | Corpus callosum/cingulum | Inter-hemispheric |
Controlled for IQ | |||||
White matter volume excesses in 22q11DS subjects | |||||
108 | 3 | −19 | −23 | Brainstem | Right |
602 | −17 | −12 | 7 | Posterior limb and genu of internal capsule and superior corona radiata | Left |
771 | 23 | −13 | 8 | Posterior limb and genu of internal capsule | Right |
210 | 22 | −75 | 19 | Posterior corona radiata, occipital lobe and superior corona radiata | Right |
85 | −36 | −2 | 30 | Pre-central gyrus | Left |