From: Role of MeCP2, DNA methylation, and HDACs in regulating synapse function
Animal model | Neuronal preparation | Long-term plasticity | Basal synaptic transmission | Favors excitation or inhibition | Reference |
---|---|---|---|---|---|
MeCP2−/y | Cortical slices from symptomatic micea | N/A | ↓spontaneous firing (also in presymptomatic miceb) | Inhibition | Dani et al. (2005) |
↓sEPSC charge | |||||
↑sIPSC charge | |||||
↓mEPSC amplitudes | |||||
Cortical slices from presymptomatic mice | Normal LTP | ↓EPSP amplitudes | Inhibition | Dani and Nelson (2009) | |
↓EPSP amplitude CV−2 | |||||
↓Connection probability | |||||
Cortical slices from symptomatic mice | N/A | ↓EPSC frequency and amplitudes | Inhibition | Tropea et al. (2009) | |
Hippocampal slices from symptomatic mice | ↓LTP and LTD | ↓fEPSP PPR | ? | Asaka et al. (2006) | |
Dissociated hippocampal cultures | N/A | ↓mEPSC frequency | Inhibition | Nelson et al. (2006) | |
↓EPSC PPR | |||||
↑10 Hz EPSC amplitude depression | |||||
Autaptic hippocampal cultures | N/A | ↓eEPSC amplitudes | Inhibition | Chao et al. (2007) | |
↓mESPC frequency | |||||
↓EPSC charge in response to hypertonic sucrose | |||||
MeCP2308/y | Hippocampal and cortical slices from symptomatic mice | Hippocampus: ↓LTP and LTD | Hippocampus: fEPSP–fiber volley slope ratio | ? | Moretti et al. (2006) |
Cortex: ↓LTP | ↓fEPSP PPR | ||||
MeCP2Tg1 | Hippocampal slices | ↑LTP | ↑fEPSP PPR | ? | Collins et al. (2004) |
Autaptic hippocampal cultures | N/A | ↑eEPSC amplitudes | Excitation | Chao et al. (2007) | |
↑mEPSC frequency | |||||
↑EPSC charge in response to hypertonic sucrose |