The neural correlates of visuo-spatial working memory in children with autism spectrum disorder: effects of cognitive load

Table 4 Linear trend analyses across difficulty levels: TD group

Linear trend analyses across difficulty levels for TD children
	Voxels	MNI Coordinates			Z value	P value	Hem.	Region
		x	y	z
Regions where activation increases with difficulty (increasing BOLD signal)	8885	−26	−90	16	5.04	1.88 × 10⁻²¹	L	Middle occipital gyrus
	X	24	−82	−10	4.93		R	Fusiform/lingual gyrus
	X	24	−62	50	4.86		R	Precuneus
	X	38	−84	10	4.78		R	Middle occipital gyrus
	X	−16	−64	56	4.25		L	Precuneus
	X	−20	−82	−14	4.22		L	Fusiform/lingual gyrus
	6845	32	26	0	4.97	7.26 × 10⁻¹⁸	R	Inferior frontal gyrus
	X	−32	24	−4	4.95		L	Inferior frontal gyrus
	X	8	28	32	4.94		R	Anterior cingulate cortex
	X	32	42	22	4.04		R	Dorsolateral prefrontal cortex
	X	−12	30	24	3.90		L	Anterior cingulate cortex
Regions where activation decreases with difficulty (decreasing BOLD signal)	1808	−6	−56	30	−3.68	9.54 × 10⁻⁷	L	Posterior cingulate gyrus
	X	4	−40	34	−3.47		R	Posterior cingulate cortex
	725	−42	−72	36	−3.69	3.29 × 10⁻³	L	Middle temporal gyrus
	629	8	48	42	−3.76	7.91 × 10⁻³	R	Medial frontal gyrus
	X	−6	62	20	−3.61		L	Medial frontal gyrus

Results from linear trend analyses from D3 to D6 for TD children. Areas that increased as a function of difficulty level (A) are associated with WM and visuo-spatial processing, whereas areas that decreased as a function of difficulty level (B) are associated with the default mode network. MNI coordinates represent the peak Z value of the cluster; X peak local maximas within cluster.

ISSN: 1866-1955