Table 3 Motor-behavioral assessment and acquired developmental milestones: gross and fine motor
From: Developmental delay in Rett syndrome: data from the natural history study
Developmental skill | Parameter estimate ± Standard error, from the generalized estimating equation after adjusting for age at enrollment (Skill not gained vs. gained) | ||
|---|---|---|---|
Classic | Atypical better | Atypical poorer | |
Rolling | 7.9 ± 2.6 (p = 0.003) | 6.9 ± 4.6 (p = 0.132) | 5.9 ± 5.4 (p = 0.274) |
Sit with support | 14.8 ± 2.6 (p < 0.0001) | N.A. | 2.2 ± 2.9 (p = 0.453) |
Sit alone | 8.7 ± 1.0 (p < 0.0001) | 10.5 ± 2.3 (p < 0.0001) | 3.5 ± 2.9 (p = 0.237) |
Crawl | 8.4 ± 0.9 (p < 0.0001) | 8.7 ± 3.1 (p = 0.005) | −0.8 ± 3.2 (p = 0.796) |
Pull to stand | 9.3 ± 0.9 (p < 0.0001) | 12.3 ± 2.0 (p < 0.0001) | 2.6 ± 2.8 (p = 0.358) |
Walk with help | 11.0 ± 1.0 (p < 0.0001) | 12.3 ± 2.8 (p < 0.0001) | 1.7 ± 3.0 (p = 0.577) |
Walk alone | 10.9 ± 0.8 (p < 0.0001) | 9.0 ± 2.4 (p = 0.0001) | 2.1 ± 4.6 (p = 0.647) |
Climb steps | 11.2 ± 1.2 (p < 0.0001) | 6.4 ± 2.8 (p = 0.023) | N.A |
Ride tricycle | 10.6 ± 3.0 (p = 0.0004) | 7.3 ± 3.0 (p = 0.015) | 12.3 ± 2.6 (p < 0.0001) |
Hold bottle | 6.4 ± 1.1 (p < 0.0001) | −2.0 ± 2.6 (p = 0.432) | 3.4 ± 2.9 (p = 0.245) |
Reach | 6.5 ± 2.7 (p = 0.015) | N.A. | 2.6 ± 3.6 (p = 0.483) |
Transfer | 4.2 ± 1.1 (p < 0.0001) | 9.8 ± 2.7 (p = 0.0003) | 7.4 ± 2.8 (p = 0.008) |
Pincer grasp | 6.0 ± 1.0 (p < 0.0001) | 10.7 ± 2.5 (p < 0.0001) | 2.8 ± 2.7 (p = 0.304) |
Finger feed | 8.3 ± 1.4 (p < 0.0001) | 16.1 ± 2.2 (p < 0.0001) | 0.8 ± 2.3 (p = 0.744) |