Fig. 7From: Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behaviorTheoretical model of Met gene dose effect on behavioral disruption. Our data indicate that intermediate expression of Met (Met fx/+/Nestin cre Het) resulted in significant behavioral deficits while the absence of Met (Met fx/fx/Nestin cre KO) only sometimes impacted behavior. The model suggests an inverse U-shaped model of atypical behavior such that an absence of Met can lead to compensatory changes in brain development. The model proposes a threshold of Met gene dosage for a behavior deficit and a second threshold of Met gene dosage that is permissive for compensatory mechanisms resulting in typical behaviorBack to article page