Table 1 Summary of sex differences in the frontal cortex
Protein measure | Brain region | N | Number of males and females per age group (P7, 14, 28, 56) | DTNBP1 genotypes included | Sex effect | Males (mean) | Females (mean) | ANOVA F statistic (main effect of sex; sex × age interaction) | ANOVA p value |
|---|---|---|---|---|---|---|---|---|---|
PSD enrichments | |||||||||
GluN2B:GluN2A | FCx | 120 | 15 M, 15 F | −/−, +/−, +/+ | M > F | 0.97 | 1.03 | Sex F(1, 96) = 4.4 | p < 0.05 |
Age F(3, 96) = 19.6 | p < 0.00001 | ||||||||
Interaction F(3, 96) = 0.9 | N.S. | ||||||||
GluN2B:GluN1 | FCx | 120 | 15 M, 15 F | −/−, +/−, +/+ | M > F | 0.94 | 1.04 | Sex F(1, 96) = 8.0 | p = 0.006 |
Age F(3, 96) = 4.6 | p < 0.005 | ||||||||
Interaction F(3, 96) = 0.2 | N.S. | ||||||||
pY1472-GluN2B: total GluN2B | FCx | 64 | 7–10 M, 6–9 F | −/−, +/+ | M > F | 0.84 | 1.14 | Sex F(1, 48) = 8.0 | p = 0.007 |
Age F(3, 48) = 10.8 | p < 0.00001 | ||||||||
Interaction F(,) = | N.S. | ||||||||
Fyn | FCx | 120a | 15 M, 15 F | −/−, +/−, +/+ | M > F | 0.89 | 1.01 | Sex F(1, 96) = 3.8 | p = 0.055 |
Age F(3, 96) = 14.1 | p < 0.00001 | ||||||||
Interaction F(3, 96) = 0.3 | N.S. | ||||||||
PLCγ | FCx | 120 | 15 M, 15 F | −/−, +/−, +/+ | M > F | 0.88 | 1.07 | Sex F(1, 96) = 8.1 | p = 0.005 |
Age F(3, 96) = 1.5 | N.S. | ||||||||
Interaction F(3, 96) = 1.2 | N.S. | ||||||||
cSM enrichments | |||||||||
GluN2B:GluN1 | FCx | 60 | 9 M, 6 F | −/−, +/−, +/+ | M > F | 0.93 | 1.07 | Sex F(1, 36) = 13.4 | p < 0.001 |
Age F(3, 36) = 14.4 | p < 0.00001 | ||||||||
Interaction F(3, 36) = 0.9 | N.S. | ||||||||
GluN2A:GluN1 | FCx | 60 | 9 M, 6 F | −/−, +/−, +/+ | M > F | 0.95 | 1.05 | Sex F(1, 36) = 8.4 | p < 0.01 |
Age F(3, 36) = 58.9 | p < 0.00001 | ||||||||
Interaction F(3, 36) = 1.8 | N.S. | ||||||||
PLCγ | FCx | 60 | 9 M, 6 F | −/−, +/−, +/+ | M > F | 0.88 | 1.07 | Sex F(1, 36) = 7.8 | p < 0.01 |
Age F(3, 36) = 32.0 | p < 0.00001 | ||||||||
Interaction F(3, 36) = 1.2 | N.S. | ||||||||