Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome

Table 1 Demography, lifetime and current history of psychiatric disorders

	22q11.2DS (n = 29)		Controls (n = 29)
Mean age (SD)	15.7 (2.8)		16.0 (2.8)
Male/female ratio	19:10		19:10
Caucasian ancestry	29		29
3 megabase deletion	29		0
Intelligence quotient (range)^a	79.52 (35–113)		108.76 (87–129)
Psychiatric diagnoses %	Lifetime^b	Current^a–e	Lifetime^b	Current^a–e
Schizophrenia spectrum disorders (F2x)^c	0	0	0	0
Affective disorders (F30-F33)^d	3.4	3.4	0	0
Anxiety and phobia (F4x)^d	3.4	34.5	0	13.8
Intellectual disability (F7x)^a	17.2	20.1	0	0
Autism spectrum disorders (F84.x)^e	13.8	13.8	0	0
Disturbance of activity and attention/attention-deficit disorder without hyperactivity (F90.0/98.8C)^d	3.4	3.4	0	0

^aIntelligence quotient score was derived from the Reynolds Intellectual Screening Test (RIST) [48]. Indication of current intellectual disability was indexed by RIST IQ below 70
^bLifetime diagnoses according to International Classification of Diseases (ICD-10) obtained from the Danish Psychiatric Central Register [51]
^cCurrent diagnosis of schizophrenia was obtained from the Structured Interview for Prodromal Syndromes
^dCurrent diagnoses of affective disorder, anxiety, and disturbance of activity and attention/attention-deficit disorder without hyperactivity were provided by use of the Mini International Neuropsychiatric Interview [45, 82] or the Mini International Neuropsychiatric Interview for Children and Adolescents [46]
^eIndications of current autism spectrum disorders (ASD) was determined from parental reporting using the Social Communication Questionnaire lifetime form. Clinical cut-off of 15 indicates ASD [49, 50]

ISSN: 1866-1955