Table 4 Summary of results from behavioural tests of auditory function in rodent models of autism. Entries are in bold font in cases where a result is represented by more than one study in a model or represents the majority of the studies in that model. Numbers in subscript brackets refer to the relevant papers from the literature search, as numbered in Supplementary Table 1. Models are listed in alphabetical order
From: Auditory processing in rodent models of autism: a systematic review
Test | Models increased compared to WT | Models unchanged compared to WT | Models decreased compared to WT |
|---|---|---|---|
Acoustic startle response (ASR) <100 dB SPL | Fmr1(45), Wnt1(52) | Cb1(21), Chd8(33), Cntn4(48), Cntnap2(47, 70), Drd2(42), Neph2(80), NR1(22, 24), Wnt1(52) | Cacnα2δ3(34) |
Acoustic startle response (ASR) >100 dB SPL | 22q11.2(11), Cntnap2(47, 70), Cntn4(48), Drd2(42), Ehmt1(9), LPS(19), NR1(22, 24) | Chd8(33), Drd2(42), MGluR5(4), Nlgn3(76), TS2(62), VPA(10) | 15q13.3(20), Fmr1(7, 55), Neph2(80), VPA(64) |
Pre-pulse inhibition (PPI) | Cntnap2(77), Fmr1(7, 55), MGluR5(4), Ube3a(56) | 15q13.3(20), Drd2(42), Cntn4(48), Shank3b(63), Slo1(79), TS2(62), VPA(10) | 22q11.2(11), Cntnap2(47, 70), Ehmt1(9), LPS(19), Nlgn3(76), NR1(22, 24), VPA(64) |
Frequency distinction (embedded tone) | Cntnap2(77), Shank3b(63), TS2(62) | Ptchd1(51), Ube3a(56) | Â |
Gap detection | TS2(62) | Shank3b(63) | Cntnap2(77) |
Complex sound distinction | Â | Fmr1(14), Mecp2(16) | VPA(13) |
Task with background noise | Â | Â | Mecp2(16), Ptchd1(51) |