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Fig. 2 | Journal of Neurodevelopmental Disorders

Fig. 2

From: Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder

Fig. 2

Summary and characterization of the human iPSCs lines from SSADH deficient patients and sex-matched unaffected parental controls. (a) Recapitulative table. (b) Representative images of the iPSCs (ALDH5A1-/- and ALDH5A1+/-) demonstrating the successful reprogramming by characterizing the expression of pluripotency markers NANOG (Nanog homeobox x in green) and TRA-1-60 (podocalyxin in magenta), OCT4 (octamer binding transcription factor 4 in green), and SOX2 (SRY-Box Transcription Factor 2 in magenta). (c) Representative image of iPSC-derived iGABA neurons labelled with DAPI (cyan), MAP2 (green), GABA (magenta). Scale bar 50 μm

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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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