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Fig. 3 | Journal of Neurodevelopmental Disorders

Fig. 3

From: Deficient maternal care resulting from immunological stress during pregnancy is associated with a sex-dependent enhancement of conditioned fear in the offspring

Fig. 3

Effects of the prenatal and postnatal maternal manipulations on the acquisition and expression of conditioned fear in the peri-adolescent offspring. a On the conditioning day, the amount of freezing (expressed as a percent of time freezing out of 30 s) during presentations of the tone conditioned stimulus is depicted as a function of trials (line plots) and average over the three conditioning trials (bar plots) for both male and female subjects. b The amount of freezing (as a percent of time) exhibited over a period of 6 min when the animals were returned to the same context where tone-shock pairings took place 24 h earlier is illustrated as a function of 1-min bins (line plots) and as an average over the 6-min period (bar plots). c The amount of freezing (as a percent of time) displayed over a period of 6 min when the animals were exposed to the same CS in a separate context 48 h following conditioning is illustrated as a function of 1-min bins (line plots) and as an average over the 6-min period (bar plots). SAL-SAL, offspring subjected to prenatal vehicle exposure and raised by vehicle-treated surrogate mothers; SAL-POL, offspring subjected to prenatal vehicle exposure and raised by PolyI:C-treated surrogate mothers; POL-SAL, offspring subjected to prenatal PolyI:C exposure and raised by vehicle-treated surrogate mothers; POL-POL, offspring subjected to prenatal PolyI:C exposure and raised by PolyI:C-treated surrogate mothers. Symbol (*) refers to a statistical significance of p < 0.05. The number of subjects in each group is listed in Table 1. All values are means ± SEM

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