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Table 2 Summary of the effects of the prenatal and postnatal maternal manipulations on the offspring’s performance in the elevated plus maze and open field exploration tests in peri-adolescence

From: Deficient maternal care resulting from immunological stress during pregnancy is associated with a sex-dependent enhancement of conditioned fear in the offspring

Experiment Experimental groups (prenatal treatment–postnatal rearing)
SAL-SAL SAL-POL POL-SAL POL-POL
Elevated plus maze     
 Total distance moved (m) 14.10 ± 2.31 15.84 ± 2.04 18.82 ± 3.83 18.27 ± 4.99
 Distance moved (m) in open arms 1.17 ± 0.24 1.31 ± 0.18 1.55 ± 0.31 1.56 ± 0.49
 Percent open arm entries 29.61 ± 3.82 26.34 ± 1.97 28.24 ± 3.44 24.34 ± 3.60
 Percent time spent in open arms 13.17 ± 2.63 9.30 ± 1.22 10.68 ± 2.18 11.72 ± 2.09
Open field     
 Total distance moved (m) 111.09 ± 8.92 119.67 ± 12.77 117.77 ± 10.38 107.39 ± 8.58
 Distance moved (m) in center zone 7.99 ± 0.88 9.24 ± 1.59 9.16 ± 0.96 8.68 ± 1.71
 Time in center zone (s) 170.96 ± 21.45 200.04 ± 38.23 195.70 ± 20.36 195.34 ± 49.58
 Center zone entries 88 ± 10 106 ± 19 106 ± 11 99 ± 20
  1. SAL-SAL, offspring subjected to prenatal vehicle exposure and raised by vehicle-treated surrogate mothers; SAL-POL, offspring subjected to prenatal vehicle exposure and raised by PolyI:C-treated surrogate mothers; POL-SAL, offspring subjected to prenatal PolyI:C exposure and raised by vehicle-treated surrogate mothers; POL-POL, offspring subjected to prenatal PolyI:C exposure and raised by PolyI:C-treated surrogate mothers. No significant group differences were detected in any of the dependent measures. All values are means±SEM