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Table 1 Studies in healthy controls relating BDNF val66met to cortical

From: A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder

First Author

Year

Sample Size

Age (years)

Gender

Measure

Findings

  

ValVal

Met

    

Pezawas

2004

69

42

M: 34 R: 18-60

mixed

VBM

Met carriers - Reduced CV in bilateral inferior and middle frontal gyri, left precuneus and superior parietal lobule, right medial frontal, precentral, superior frontal, postcentral gyri. Val homozygotes - Reduced CV in right middle frontal and lingual gyri.

Agartz

2006

66

30

M: 42

mixed

Automated lobar CV

No significant effect of genotype

Nemoto

2006

41

68

M: 36 R: 20-72

mixed

VBM

Met carriers - reduced CV in left parahippocampal gyrus.

Varnas

2008

73

31

M: 42

mixed

Cortical Thickness

Trend towards association between genotype and CV in left frontal (straight gyrus, transverse frontopolar, superior frontal) and right frontal (pars triangularis) cortices. No effect of genotype on regional CT

Schofield

2008

96

59

M: 32 R: 20-60

mixed

VBM

No effect of genotype in regional CV

  1. Abbreviations: M Mean, R Range, VBM Voxel Based Morphometry, CV Cortical Volume, CT cortical thickness