Fig. 2
From: Fragile x syndrome and autism: from disease model to therapeutic targets
Autism as a synapsopathy. mGluR5 interacts with a number of postsynaptic proteins. Some of these have been identified as autism candidate genes (shown in purple; HOMER, SHANK, Neuroligin, Neurexin); others are proteins associated with single gene causes of autism (shown in red: FMRP/FXS, TSC/Tuberous Sclerosis, PTEN/ Hamartoma syndrome, MeCP2/Rett syndrome, E3A/Angelman’s syndrome)