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Table 1 Characteristics of the participants across analyses

From: Autistic behavior in boys with fragile X syndrome: social approach and HPA-axis dysfunction

Analysis Series

Participant Groups

Analysis 1: SAS Profiles

Typically Developing Group

FXS-only

FXS + ASD

(n = 21)

(n = 33)

(n = 18)

(Mean ± SD)

(Mean ± SD)

(Mean ± SD)

Chronological Age (Years)bc

4.05 ± 1.95

3.99 ± 2.25

8.13 ± 3.55

Vineland Adaptive Behavior Compositeabc

98.7 ± 10.7

62.7 ± 12.1

41.1 ± 13.3

Childhood Autism Rating Scale Totalc

N/A

24.8 ± 3.2

34.0 ± 3.7

Analysis 2: Cortisol

(n = 63)

(n = 53)

(n = 11)

(Mean ± SD)

(Mean ± SD)

(Mean ± SD)

Chronological Age (Years)ab

4.88 ± 1.39

7.5 ± 4.06

7.46 ± 4.16

Vineland Adaptive Behavior Compositeabc

98.7 ± 10.7

55.7 ± 16.0

43.5 ± 13.1

Childhood Autism Rating Scale Totalc

N/A

24.8 ± 3.1

33.7 ± 3.3

Analysis 3: Behavior Ratings and Cortisol

Cortisol-SAS

(n = 21)

(n = 34)

(n = 9)

(Mean ± SD)

(Mean ± SD)

(Mean ± SD)

Chronological Age (Years)bc

4.05 ± 1.95

3.99 ± 2.25

8.13 ± 3.55

Vineland Adaptive Behavior Compositeabc

98.7 ± 10.7

62.7 ± 12.1

41.1 ± 13.3

Childhood Autism Rating Scale Total c

N/A

24.8 ± 3.2

34.0 ± 3.7

Cortisol-CARS

(N/A)

(n = 40)

(n = 10)

(Mean ± SD)

(Mean ± SD)

(Mean ± SD)

Chronological Age (Years)

N/A

8.03 ± 3.95

7.9 ± 4.1

Vineland Adaptive Behavior Compositec

N/A

55.1 ± 13.5

41.0 ± 13.1

Childhood Autism Rating Scale Totalc

N/A

24.6 ± 3.1

32.7 ± 2.0

  1. aSignificant difference between Typically Developing Group and FXS-only
  2. bSignificant difference between Typically Developing Group and FXS + ASD
  3. cSignificant difference between FXS-only and FXS + ASD