Skip to main content

Table 1 CHT Genotypes in ADHD Vanderbilt and Chicago Cohort versus healthy controls

From: Choline transporter gene variation is associated with attention-deficit hyperactivity disorder

Group Subgroup Gender (%) Ethnicity (%) Genotype (n) Allele Frequency (%)
Ile89Val (rs1013940) Male Female White Black A/A A/G G/G A G
Control panel ( n  = 290) 121 (42%) 169 (58%) 127 (44%) 163 (56%) 260 27 3 94 6
  Caucasian (n = 127) 65 (51%) 62 (49%) 127 (100%) - 111 15 1 93 7
  Caucasian male (n = 65) 65 (100%) - 65 (100%) - 59 5 1 95 5
ADHD panel ( n  = 100) 76 (76%) 24 (24%) 81 (81%) 19 (19%) 78 21 1 88 12
Caucasian only (n = 81)   61 (75%) 20 (25%) 81 (100%) - 60 20 1 86 14
  Hyperactive 4 (5%) 0 4 (5%) - 4 0 0 100 0
  Combined 41 (51%) 10 (12%) 51 (63%) - 39 13 1 86 14
  Inattentive 13 (16%) 10 (12%) 23 (28%) - 17 7 0 85 15
Caucasian male only (n = 61)   61 (100%) - 61 - 44 16 1 85 15
  Hyperactive 5 (9%) - 5 - 4 1 0 90 10
  Combined 41 (67%) - 41 - 30 10 1 85 15
  Inattentive 15 (25%) - 15 - 10 5 0 83 17
3’SNP (rs333229)
Control panel (n = 233) 109 (47%) 118 (51%) 127 (55%) 91 (39%) 121 87 19 71 27
  Caucasian 64 (27%) 63 (27%) 127 (55%) - 73 46 8 76 24
  Caucasian male 64 (27%) - 64 (27%) - 39 23 2 79 21
ADHD panel ( n  = 100) 76 (76%) 24 (24%) 81 (81%) 19 (19%) 64 30 6 79 21
Diagnosis subtype (n = 96) Hyperactive 4 (4%) 1 (1%) 4 (4%) 1 (1%) 3 2 0 80 20
  Combined 50 (52%) 11 (11%) 52 (54%) 9 (9%) 41 18 2 82 18
  Inattentive 18 (19%) 12 (13%) 23 (24%) 4 94%) 19 7 4 75 25
Caucasian only (n = 80)   60 (75%) 20 (25%) 80 (100%) - 57 20 2 84 16
  Hyperactive 4 (5%) 0 4 (5%) - 3 1 0 88 12
  Combined 41 (51%) 10 (13%) 51 (64%) - 36 14 1 84 16
  Inattentive 13 (16%) 10 (13%) 23 (29%)   18 4 1 87 13
Caucasian male only (n = 60)   60 (100%) - 60 (100%) - 46 12 2 87 13
  Hyperactive 4 (7%) - 4 (7%) - 3 1 0 88 12
  Combined 41 (68%) - 41 (68%) - 31 9 1 87 13
  Inattentive 13 (22%) - 13 (22%) - 11 1 1 88 12