Table 1 CHT Genotypes in ADHD Vanderbilt and Chicago Cohort versus healthy controls
From: Choline transporter gene variation is associated with attention-deficit hyperactivity disorder
Group | Subgroup | Gender (%) | Ethnicity (%) | Genotype (n) | Allele Frequency (%) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Ile89Val (rs1013940) | Male | Female | White | Black | A/A | A/G | G/G | A | G | |
Control panel ( n  = 290) | 121 (42%) | 169 (58%) | 127 (44%) | 163 (56%) | 260 | 27 | 3 | 94 | 6 | |
|  | Caucasian (n = 127) | 65 (51%) | 62 (49%) | 127 (100%) | - | 111 | 15 | 1 | 93 | 7 |
|  | Caucasian male (n = 65) | 65 (100%) | - | 65 (100%) | - | 59 | 5 | 1 | 95 | 5 |
ADHD panel ( n  = 100) | 76 (76%) | 24 (24%) | 81 (81%) | 19 (19%) | 78 | 21 | 1 | 88 | 12 | |
Caucasian only (n = 81) |  | 61 (75%) | 20 (25%) | 81 (100%) | - | 60 | 20 | 1 | 86 | 14 |
| Â | Hyperactive | 4 (5%) | 0 | 4 (5%) | - | 4 | 0 | 0 | 100 | 0 |
| Â | Combined | 41 (51%) | 10 (12%) | 51 (63%) | - | 39 | 13 | 1 | 86 | 14 |
| Â | Inattentive | 13 (16%) | 10 (12%) | 23 (28%) | - | 17 | 7 | 0 | 85 | 15 |
Caucasian male only (n = 61) |  | 61 (100%) | - | 61 | - | 44 | 16 | 1 | 85 | 15 |
| Â | Hyperactive | 5 (9%) | - | 5 | - | 4 | 1 | 0 | 90 | 10 |
| Â | Combined | 41 (67%) | - | 41 | - | 30 | 10 | 1 | 85 | 15 |
| Â | Inattentive | 15 (25%) | - | 15 | - | 10 | 5 | 0 | 83 | 17 |
3’SNP (rs333229) | ||||||||||
Control panel (n = 233) | 109 (47%) | 118 (51%) | 127 (55%) | 91 (39%) | 121 | 87 | 19 | 71 | 27 | |
| Â | Caucasian | 64 (27%) | 63 (27%) | 127 (55%) | - | 73 | 46 | 8 | 76 | 24 |
| Â | Caucasian male | 64 (27%) | - | 64 (27%) | - | 39 | 23 | 2 | 79 | 21 |
ADHD panel ( n  = 100) | 76 (76%) | 24 (24%) | 81 (81%) | 19 (19%) | 64 | 30 | 6 | 79 | 21 | |
Diagnosis subtype (n = 96) | Hyperactive | 4 (4%) | 1 (1%) | 4 (4%) | 1 (1%) | 3 | 2 | 0 | 80 | 20 |
| Â | Combined | 50 (52%) | 11 (11%) | 52 (54%) | 9 (9%) | 41 | 18 | 2 | 82 | 18 |
| Â | Inattentive | 18 (19%) | 12 (13%) | 23 (24%) | 4 94%) | 19 | 7 | 4 | 75 | 25 |
Caucasian only (n = 80) |  | 60 (75%) | 20 (25%) | 80 (100%) | - | 57 | 20 | 2 | 84 | 16 |
| Â | Hyperactive | 4 (5%) | 0 | 4 (5%) | - | 3 | 1 | 0 | 88 | 12 |
| Â | Combined | 41 (51%) | 10 (13%) | 51 (64%) | - | 36 | 14 | 1 | 84 | 16 |
| Â | Inattentive | 13 (16%) | 10 (13%) | 23 (29%) | Â | 18 | 4 | 1 | 87 | 13 |
Caucasian male only (n = 60) |  | 60 (100%) | - | 60 (100%) | - | 46 | 12 | 2 | 87 | 13 |
| Â | Hyperactive | 4 (7%) | - | 4 (7%) | - | 3 | 1 | 0 | 88 | 12 |
| Â | Combined | 41 (68%) | - | 41 (68%) | - | 31 | 9 | 1 | 87 | 13 |
| Â | Inattentive | 13 (22%) | - | 13 (22%) | - | 11 | 1 | 1 | 88 | 12 |