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Table 4 Association of the CHT Val89 and 3’SNP minor allele with ADHD and the combined and inattentive predominant diagnoses

From: Choline transporter gene variation is associated with attention-deficit hyperactivity disorder

Diagnosis ADHD (offset = .14)* Combined (offset = .06) Inattentive (offset = .08)
χ2 / Z P R2 OR χ2 / Z P R2 OR χ2 / Z P R2 OR
Modela
Additive [Multimarker] 0.457 .324    -.906 .817    -.233 .592   
Omnibus χ2 Test 0.855 .836    8.482 .037    2.396 .494   
Test of risk haplotype 0.742 .458 .002 1.18 2.653 .008 .048 2.25 0.412 .681 .00 1.09
Dominant [Multimarker] 0.777 .219    0.184 .427    0.861 .195   
Omnibus χ2 Test 1.063 .900    8.159 .086    3.812 .432   
Test of risk haplotype 0.742 .458 .003 1,21 2.653 .008 .069 2.68 0.412 .681 .001 1.11
Recessive [Multimarker] -0.362 .641    -1.771 .962    -.558 .712   
Omnibus χ2 Test 0.661 .882    4.764 .190    1.563 .668   
Test of risk haplotype NA NA NA NA NA NA NA NA NA NA NA NA
  1. NA indicates that there were too few informative families to test the target haplotype
  2. aIn all models, ADHD cases were contrasted with unaffected individuals, or individuals with the target ADHD subtype were contrasted with both unaffected individuals and individuals diagnosed with the other ADHD subtypes. Omnibus χ2 tests of all 4 haplotypes had 3 degrees-of-freedom and were evaluated using a two-tailed p-value, Z tests of the risk haplotype (i.e., the G-C haplotype comprising the minor alleles for both CHT SNPs) had 1 degree-of-freedom and were evaluated using a two-tailed p-value