Fig. 5
From: Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development
Role for both branches of TGF-β signaling in tangential migration of GABAergic interneurons in the developing telencephalon. Organotypic cultures of E12.5 forebrain slices from different levels of the rostrocaudal axis were focally electroporated into the MGE or CGE with a GFP expression vector alone (left hemisphere; panels a-l) or with a combination of GFP and dominant-negative Smad1 (Smad1-DN) (A) or dominant negative Smad2 (Smad2-DN) (B) (right hemisphere; shown in each case in panels a′-l′). Slices were photographed after 12, 36, 60 and 84 h to visualize the tangential migration of GFP-expressing cells from the MGE or CGE. Decreased cell migration towards the neocortex was observed in the hemisphere electroporated with dominant-negative Smad forms