Table 1 Microarray analysis of the expression of TGF-β superfamily components in the developing subpallium
From: Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development
Value WT | Value Dlx1/2−/− | ||
|---|---|---|---|
A) BMP/GDF→ALK 1/2/3/6→Smad 1/5/8 pathway | |||
Ligand | Gdfl0 | 63 | 55 |
Gdfl1 | 57 | 38 | |
Gdfl5 | 56 | 16 | |
Gdf2 | 46 | 35 | |
Gdf3 | 46 | 20 | |
Gdf9 | 42 | 44 | |
Gdf5 | 30 | 12 | |
Receptor | BMP-RIA (ALK-3) | 300 | 491 |
ActRI (ALK-2) | 281 | 235 | |
ActRII | 236 | 254 | |
ActRIIB | 230 | 248 | |
BMP-RIB (ALK-6) | 74 | 76 | |
BMPRII | 82 | 93 | |
Smad | Smad4 | 2060 | 1837 |
Smad1 | 711 | 729 | |
Smad5 | 239 | 205 | |
Smad7 | 44 | 67 | |
B) TGF-β/activin Nodal→ALK4/5/7→Smad 2/3 pathway | |||
Ligand | TGFβ1 | 108 | 81 |
TGFβ2 | 59 | 76 | |
TGFβ3 | 38 | 13 | |
Receptor | TGFβ-RI (ALK-5) | 638 | 706 |
TGFβ-RII | 36 | 25 | |
ActRII | 236 | 254 | |
ActRIIB | 230 | 248 | |
Smad | Smad4 | 2060 | 1837 |
Smad2 | 283 | 337 | |
Smad3 | 58 | 14 | |
Smad7 | 44 | 67 | |
C) Dlx transcription factors | |||
Dlx | Dlx1 | 1237 | 15 |
Dlx2 | 287 | 8 | |
Dlx5 | 706 | 71 | |
Dlx6 | 140 | 20 | |