Fig. 2

Brain activation differences between Williams syndrome (WS) and typically developing individuals (TD). a Region-of-interest (ROI) analyses in standard space of the right (Rt) medial and lateral orbitofrontal cortex (OFC). Left OFC and bilateral amygdala showed no significant differences and hence are not shown. Results comparing between groups for the contrast Positive > Negative are shown. Bar graphs represent contrast estimates (linear combination of beta weights) extracted from each individual subject from significant voxels. Error bars represent standard error. Peak of Rt lateral OFC (Talairach coordinates: 50 41 -5) corresponds to Rt lateral orbital gyrus (LOG) and Rt medial OFC (Talairach coordinates: 2 48 -14) to Rt medial orbital gyrus (MOG) according to Chiavaras et al. (2001). b ROI analyses in native space of bilateral medial and lateral OFC and the amygdala. Significant voxels (%) in each ROI as a function of Group (WS vs. TD) and contrast (Positive > Control, Negative > Control, Positive > Negative). Error bars represent standard error. ∼*: p < 0.1, *: p < 0.05, **: p < 0.01