Table 2 Cluster localisation for significant differences in white matter fractional anisotropy (FA)
DT-MRI group mapping of white matter FA of 22q11DS subjects vs. controls (cluster significance thresholdp = 0.0005) | |||||
|---|---|---|---|---|---|
Not controlled for IQ | |||||
White matter FA deficits in 22q11DS subjects | |||||
Cluster size (number of voxels) | Talairach and Tournoux coordinates | Region/tract | Hemisphere | ||
x | y | z | |||
378 | −23 | −22 | 23 | Internal capsule (posterior limb)/superior region of the corona radiata/tapetum/posterior thalamic radiation/arcuate fasciculus | Left |
White matter FA excesses in 22q11DS subjects | |||||
463 | −13 | 5 | 0 | Genu and anterior limb of internal capsule/anterior and superior portions of the corona radiata | Left |
Controlled for IQ | |||||
White matter FA deficits in 22q11DS subjects | |||||
201 | −13 | −15 | −11 | Brainstem including corticopontine and corticospinal tracts and middle cerebellar peduncle | Left |
280 | 30 | −25 | −4 | Internal capsule (retrolenticular and posterior limbs)/inferior fronto-occipital fasciculus/inferior longitudinal fasciculus/hippocampus | Right |
180 | −21 | −20 | 5 | Posterior limb of internal capsule/hippocampus | Left |
699 | −9 | −37 | 11 | Splenium of corpus callosum/superior corona radiata | Left |
752 | 14 | −39 | 13 | Splenium of corpus callosum/superior corona radiata | Right |
150 | 9 | −2 | 22 | Body of corpus callosum/cingulum | Right |