Skip to main content

Table 2 Cluster localisation for significant differences in white matter fractional anisotropy (FA)

From: White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents

DT-MRI group mapping of white matter FA of 22q11DS subjects vs. controls (cluster significance thresholdp = 0.0005)
Not controlled for IQ
White matter FA deficits in 22q11DS subjects
Cluster size (number of voxels) Talairach and Tournoux coordinates Region/tract Hemisphere
x y z
378 −23 −22 23 Internal capsule (posterior limb)/superior region of the corona radiata/tapetum/posterior thalamic radiation/arcuate fasciculus Left
White matter FA excesses in 22q11DS subjects
463 −13 5 0 Genu and anterior limb of internal capsule/anterior and superior portions of the corona radiata Left
Controlled for IQ
White matter FA deficits in 22q11DS subjects
201 −13 −15 −11 Brainstem including corticopontine and corticospinal tracts and middle cerebellar peduncle Left
280 30 −25 −4 Internal capsule (retrolenticular and posterior limbs)/inferior fronto-occipital fasciculus/inferior longitudinal fasciculus/hippocampus Right
180 −21 −20 5 Posterior limb of internal capsule/hippocampus Left
699 −9 −37 11 Splenium of corpus callosum/superior corona radiata Left
752 14 −39 13 Splenium of corpus callosum/superior corona radiata Right
150 9 −2 22 Body of corpus callosum/cingulum Right