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Table 3 Genetic influence of COMT allele variation on white matter fractional anisotropy (FA) and volume

From: White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents

White matter FA reduction of 22q11DS subjects withVCOMT vs. MCOMT (cluster significance thresholdp = 0.00175)
MCOMT > VCOMT FA
Cluster size (number of voxels) Talairach and Tournoux coordinates Region/tract Hemisphere
x y z
2721 −7 −6 26 Anterior cingulum/frontal lobe/corpus callosum Bilateral
Forceps minor/inferior fronto-occipital and uncinate fasciculi/anterior and superior corona radiata Right
White matter volume reduction of 22q11DS subjects withVCOMT vs. MCOMT (cluster significance thresholdp = 0.005)
MCOMT > VCOMT Volume
Cluster size (number of voxels) Talairach and Tournoux Coordinates Region Hemisphere
x y z
212 −36 −35 −2 Hippocampus and superior/middle/inferior temporal gyri Left
374 7 20 6 Anterior limb of internal capsule Right
329 25 −2 11 Retrolenticular limb of internal capsule Right
4924 8 −14 28 Cingulum and corpus callosum Bilateral
213 30 −36 31 Supramarginal gyrus Right