White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents

Table 3 Genetic influence of COMT allele variation on white matter fractional anisotropy (FA) and volume

White matter FA reduction of 22q11DS subjects with^VCOMT vs. ^MCOMT (cluster significance thresholdp = 0.00175)
^MCOMT > ^VCOMT FA
Cluster size (number of voxels)	Talairach and Tournoux coordinates			Region/tract	Hemisphere
Cluster size (number of voxels)	x	y	z	Region/tract	Hemisphere
2721	−7	−6	26	Anterior cingulum/frontal lobe/corpus callosum	Bilateral
2721	−7	−6	26	Forceps minor/inferior fronto-occipital and uncinate fasciculi/anterior and superior corona radiata	Right
White matter volume reduction of 22q11DS subjects with^VCOMT vs. ^MCOMT (cluster significance thresholdp = 0.005)
^MCOMT > ^VCOMT Volume
Cluster size (number of voxels)	Talairach and Tournoux Coordinates			Region	Hemisphere
Cluster size (number of voxels)	x	y	z	Region	Hemisphere
212	−36	−35	−2	Hippocampus and superior/middle/inferior temporal gyri	Left
374	7	20	6	Anterior limb of internal capsule	Right
329	25	−2	11	Retrolenticular limb of internal capsule	Right
4924	8	−14	28	Cingulum and corpus callosum	Bilateral
213	30	−36	31	Supramarginal gyrus	Right

ISSN: 1866-1955