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Table 4 Cluster localisation for significant differences in white matter volume

From: White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents

VBM analysis of white matter volume of 22q11DS subjects vs. controls (cluster significance thresholdp = 0.006)

Not controlled for IQ

White matter volume deficits in 22q11DS subjects

Cluster size (number of voxels)

Talairach and Tournoux Coordinates

Region

Hemisphere

x

y

z

4218

1

−36

−11

Brainstem/cerebellum

Right

149

34

−19

−9

Hippocampus

Right

77

−33

−35

−2

Hippocampus

Left

533

28

−71

6

Middle occipital gyrus/optic radiation and lingual, middle and inferior occipital gyri/cuneus and precuneus

Right

688

8

−11

23

Body, genu and splenium of corpus callosum

Inter-hemispheric

489

−12

−17

52

Medial frontal gyrus/paracentral lobule

Left

White matter volume excesses in 22q11DS subjects

133

−8

28

−15

Corpus callosum/cingulum/medial frontal gyrus

Left

459

−13

5

1

Globus pallidus/anterior limb and genu of internal capsule

Left

396

20

1

3

Putamen/anterior limb and genu of internal capsule

Right

341

2

−13

25

Corpus callosum/cingulum

Inter-hemispheric

Controlled for IQ

White matter volume excesses in 22q11DS subjects

108

3

−19

−23

Brainstem

Right

602

−17

−12

7

Posterior limb and genu of internal capsule and superior corona radiata

Left

771

23

−13

8

Posterior limb and genu of internal capsule

Right

210

22

−75

19

Posterior corona radiata, occipital lobe and superior corona radiata

Right

85

−36

−2

30

Pre-central gyrus

Left