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Table 4 Cluster localisation for significant differences in white matter volume

From: White matter microstructure in 22q11 deletion syndrome: a pilot diffusion tensor imaging and voxel-based morphometry study of children and adolescents

VBM analysis of white matter volume of 22q11DS subjects vs. controls (cluster significance thresholdp = 0.006)
Not controlled for IQ
White matter volume deficits in 22q11DS subjects
Cluster size (number of voxels) Talairach and Tournoux Coordinates Region Hemisphere
x y z
4218 1 −36 −11 Brainstem/cerebellum Right
149 34 −19 −9 Hippocampus Right
77 −33 −35 −2 Hippocampus Left
533 28 −71 6 Middle occipital gyrus/optic radiation and lingual, middle and inferior occipital gyri/cuneus and precuneus Right
688 8 −11 23 Body, genu and splenium of corpus callosum Inter-hemispheric
489 −12 −17 52 Medial frontal gyrus/paracentral lobule Left
White matter volume excesses in 22q11DS subjects
133 −8 28 −15 Corpus callosum/cingulum/medial frontal gyrus Left
459 −13 5 1 Globus pallidus/anterior limb and genu of internal capsule Left
396 20 1 3 Putamen/anterior limb and genu of internal capsule Right
341 2 −13 25 Corpus callosum/cingulum Inter-hemispheric
Controlled for IQ
White matter volume excesses in 22q11DS subjects
108 3 −19 −23 Brainstem Right
602 −17 −12 7 Posterior limb and genu of internal capsule and superior corona radiata Left
771 23 −13 8 Posterior limb and genu of internal capsule Right
210 22 −75 19 Posterior corona radiata, occipital lobe and superior corona radiata Right
85 −36 −2 30 Pre-central gyrus Left