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Fig. 2 | Journal of Neurodevelopmental Disorders

Fig. 2

From: Enhanced prefrontal serotonin 5-HT1A currents in a mouse model of Williams-Beuren syndrome with low innate anxiety

Fig. 2

Serotonergic currents in layer V pyramidal neurons mediated by 5-HT1A receptors in wildtype (WT) and Gtf2ird1−/− mice. In neurons from each genotype, (1.) the 5-HT-elicited outward currents were suppressed by (2.) the selective antagonist of 5-HT1A receptors, WAY-100635 (30 nM, 10 min). Gray bar indicates 5-HT application. All the above traces were recorded after application of TTX (2 µM, 10 min), indicating that the 5-HT outward currents were mediated directly by 5-HT1A receptors located on the recorded cells

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