Fig. 3

Stimulation of two other G_i/o-coupled receptors implicated in anxiety produces similar responses in layer V pyramidal neurons in both wildtype (WT) and Gtf2ird1^−/− mice. a The mGluR_2/3 agonist t-APDC (30 µM, 30 s) induces similar responses in both genotypes (WT: 21 ± 6 pA; Gtf2ird1^−/− mice: 24 ± 7 pA; P = NS). Gray bars denote t-APDC application. b Moreover, the GABA_B agonist baclofen (3 µM, 15 s) elicits similar responses in both genotypes (WT: 55 ± 6 pA; Gtf2ird1^−/− mice: 66 ± 9 pA; P = NS). Gray bars indicate baclofen application