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Table 1 The number and percentage of medical problems in patients with FXS ≥ 40 years

From: Aging in fragile X syndrome

Problems

Sexa

DNA Statusb

Total subjects (n = 62)

n

Male (n = 44)

Female (n = 18)

p

n

Full mutation ( n = 46)

Mosaic (n = 14)

p

All neurological problems

62

21 (47.7%)

3(16.7%)

0.021*

60

19(41.3%)

3(21.4%)

0.150

24(38.7%)

Movement disorder

62

17(38.6%)

2(10.2%)

0.029*

60

14(30.4%)

3(21.4%)

0.386

19(30.6%)

 • Tremor

62

8(18.2%)

1(5.6%)

0.192

60

7(15.2%)

2(14.3%)

0.651

9(14.5%)

 • Ataxia

62

6(13.6%)

1(5.6%)

0.336

60

4(8.7%)

3(21.4%)

0.199

7(11.3%)

 • Parkinsonism

62

4(9.1%)

0

0.243

60

2(4.3%)

2(14.3%)

0.230

4(6.5%)

 • Tardive dyskinesia

62

4(9.1%)

0

0.243

60

1(2.2%)

1(7.1%)

0.415

4(6.5%)

 • Bradykinesia without PD

62

5(11.4%)

0

0.168

60

5(10.9%)

0

0.251

5(8.1%)

 • Tics

62

2(4.5%)

1(5.6%)

0.650

60

3(6.5%)

0

0.444

3(4.8%)

Seizure

62

10(22.7%)

2 (11.1%)

0.249

60

10(21.7%)

1(7.1%)

0.205

12(19.4%)

Multiple Sclerosis

62

1(2.3%)

0

0.710

60

0

0

 

1(1.6%)

Gastrointestinal Problem

62

14(31.8%)

5(27.8%)

0.503

60

13(28.3%)

4(28.6%)

0.614

19(30.6%)

Obesity

52#

5(13.9%)

10(62.5%)

0.001*

51$

12(30.0%)

3(27.3%)

0.589

15(28.8%)

Hypertension

62

9(20.5%)

6(33.3%)

0.224

60

12 (26.1%)

2(14.3%)

0.300

15(24.2%)

Heart problem

62

13(29.5%)

2(11.1%)

0.110

60

12 (26.1%)

2(14.3%)

0.300

15(24.2%)

History of Decline

62

10(22.7%)

4(22.2%)

0.437

60

9(19.6%)

3(21.4%)

0.574

14(22.6%)

Autonomic problem

62

9(20.5%)

2(11.1%)

0.316

60

7(15.2%)

3(21.4%)

0.426

11(17.7%)

Memory problem

62

9(20.5%)

2(11.1%)

0.316

60

8(17.4%)

3(21.4%)

0.502

11(17.7)

Dementia/cognitive decline

62

4(9.1%)

2(11.1%)

0.567

60

4(8.7%)

1(7.1%)

0.669

6 (9.7%)

Kidney Problem

62

5(11.4%)

2(11.1%)

0.674

60

6(13.0%)

1(7.1%)

0.478

7(11.3%)

Respiratory Problem

62

4(9.1%)

2(11.1%)

0.567

60

4(8.7%)

1(7.1%)

0.669

6(9.7%)

Swallowing Problem

62

4(9.1%)

0

0.243

60

2 (4.3%)

1(7.1%)

0.556

4(6.5%)

Diabetes

62

3(6.8%)

1(5.6%)

0.671

60

3(6.5%)

1(7.1%)

0.665

4(6.5%)

Thyroid problems

62

3(6.8%)

1(5.6%)

0.671

60

3(6.5%)

1(7.1)0

0.665

4(6.5%)

Cancer

62

2 (4.5%)

0

0.500

60

0

1(7.15)

0.233

2(3.2%)

  1. • Percentage within sexa and DNA statusb
  2. • # n = 52, male = 36, female = 16 ; $ n = 51, full = 40, mosaic = 11