Problems | Sexa | DNA Statusb | Total subjects (n = 62) | ||||||
---|---|---|---|---|---|---|---|---|---|
n | Male (n = 44) | Female (n = 18) | p | n | Full mutation ( n = 46) | Mosaic (n = 14) | p | ||
All neurological problems | 62 | 21 (47.7%) | 3(16.7%) | 0.021* | 60 | 19(41.3%) | 3(21.4%) | 0.150 | 24(38.7%) |
Movement disorder | 62 | 17(38.6%) | 2(10.2%) | 0.029* | 60 | 14(30.4%) | 3(21.4%) | 0.386 | 19(30.6%) |
 • Tremor | 62 | 8(18.2%) | 1(5.6%) | 0.192 | 60 | 7(15.2%) | 2(14.3%) | 0.651 | 9(14.5%) |
 • Ataxia | 62 | 6(13.6%) | 1(5.6%) | 0.336 | 60 | 4(8.7%) | 3(21.4%) | 0.199 | 7(11.3%) |
 • Parkinsonism | 62 | 4(9.1%) | 0 | 0.243 | 60 | 2(4.3%) | 2(14.3%) | 0.230 | 4(6.5%) |
 • Tardive dyskinesia | 62 | 4(9.1%) | 0 | 0.243 | 60 | 1(2.2%) | 1(7.1%) | 0.415 | 4(6.5%) |
 • Bradykinesia without PD | 62 | 5(11.4%) | 0 | 0.168 | 60 | 5(10.9%) | 0 | 0.251 | 5(8.1%) |
 • Tics | 62 | 2(4.5%) | 1(5.6%) | 0.650 | 60 | 3(6.5%) | 0 | 0.444 | 3(4.8%) |
Seizure | 62 | 10(22.7%) | 2 (11.1%) | 0.249 | 60 | 10(21.7%) | 1(7.1%) | 0.205 | 12(19.4%) |
Multiple Sclerosis | 62 | 1(2.3%) | 0 | 0.710 | 60 | 0 | 0 | Â | 1(1.6%) |
Gastrointestinal Problem | 62 | 14(31.8%) | 5(27.8%) | 0.503 | 60 | 13(28.3%) | 4(28.6%) | 0.614 | 19(30.6%) |
Obesity | 52# | 5(13.9%) | 10(62.5%) | 0.001* | 51$ | 12(30.0%) | 3(27.3%) | 0.589 | 15(28.8%) |
Hypertension | 62 | 9(20.5%) | 6(33.3%) | 0.224 | 60 | 12 (26.1%) | 2(14.3%) | 0.300 | 15(24.2%) |
Heart problem | 62 | 13(29.5%) | 2(11.1%) | 0.110 | 60 | 12 (26.1%) | 2(14.3%) | 0.300 | 15(24.2%) |
History of Decline | 62 | 10(22.7%) | 4(22.2%) | 0.437 | 60 | 9(19.6%) | 3(21.4%) | 0.574 | 14(22.6%) |
Autonomic problem | 62 | 9(20.5%) | 2(11.1%) | 0.316 | 60 | 7(15.2%) | 3(21.4%) | 0.426 | 11(17.7%) |
Memory problem | 62 | 9(20.5%) | 2(11.1%) | 0.316 | 60 | 8(17.4%) | 3(21.4%) | 0.502 | 11(17.7) |
Dementia/cognitive decline | 62 | 4(9.1%) | 2(11.1%) | 0.567 | 60 | 4(8.7%) | 1(7.1%) | 0.669 | 6 (9.7%) |
Kidney Problem | 62 | 5(11.4%) | 2(11.1%) | 0.674 | 60 | 6(13.0%) | 1(7.1%) | 0.478 | 7(11.3%) |
Respiratory Problem | 62 | 4(9.1%) | 2(11.1%) | 0.567 | 60 | 4(8.7%) | 1(7.1%) | 0.669 | 6(9.7%) |
Swallowing Problem | 62 | 4(9.1%) | 0 | 0.243 | 60 | 2 (4.3%) | 1(7.1%) | 0.556 | 4(6.5%) |
Diabetes | 62 | 3(6.8%) | 1(5.6%) | 0.671 | 60 | 3(6.5%) | 1(7.1%) | 0.665 | 4(6.5%) |
Thyroid problems | 62 | 3(6.8%) | 1(5.6%) | 0.671 | 60 | 3(6.5%) | 1(7.1)0 | 0.665 | 4(6.5%) |
Cancer | 62 | 2 (4.5%) | 0 | 0.500 | 60 | 0 | 1(7.15) | 0.233 | 2(3.2%) |