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Table 1 The number and percentage of medical problems in patients with FXS ≥ 40 years

From: Aging in fragile X syndrome

Problems Sexa DNA Statusb Total subjects (n = 62)
n Male (n = 44) Female (n = 18) p n Full mutation ( n = 46) Mosaic (n = 14) p
All neurological problems 62 21 (47.7%) 3(16.7%) 0.021* 60 19(41.3%) 3(21.4%) 0.150 24(38.7%)
Movement disorder 62 17(38.6%) 2(10.2%) 0.029* 60 14(30.4%) 3(21.4%) 0.386 19(30.6%)
 • Tremor 62 8(18.2%) 1(5.6%) 0.192 60 7(15.2%) 2(14.3%) 0.651 9(14.5%)
 • Ataxia 62 6(13.6%) 1(5.6%) 0.336 60 4(8.7%) 3(21.4%) 0.199 7(11.3%)
 • Parkinsonism 62 4(9.1%) 0 0.243 60 2(4.3%) 2(14.3%) 0.230 4(6.5%)
 • Tardive dyskinesia 62 4(9.1%) 0 0.243 60 1(2.2%) 1(7.1%) 0.415 4(6.5%)
 • Bradykinesia without PD 62 5(11.4%) 0 0.168 60 5(10.9%) 0 0.251 5(8.1%)
 • Tics 62 2(4.5%) 1(5.6%) 0.650 60 3(6.5%) 0 0.444 3(4.8%)
Seizure 62 10(22.7%) 2 (11.1%) 0.249 60 10(21.7%) 1(7.1%) 0.205 12(19.4%)
Multiple Sclerosis 62 1(2.3%) 0 0.710 60 0 0   1(1.6%)
Gastrointestinal Problem 62 14(31.8%) 5(27.8%) 0.503 60 13(28.3%) 4(28.6%) 0.614 19(30.6%)
Obesity 52# 5(13.9%) 10(62.5%) 0.001* 51$ 12(30.0%) 3(27.3%) 0.589 15(28.8%)
Hypertension 62 9(20.5%) 6(33.3%) 0.224 60 12 (26.1%) 2(14.3%) 0.300 15(24.2%)
Heart problem 62 13(29.5%) 2(11.1%) 0.110 60 12 (26.1%) 2(14.3%) 0.300 15(24.2%)
History of Decline 62 10(22.7%) 4(22.2%) 0.437 60 9(19.6%) 3(21.4%) 0.574 14(22.6%)
Autonomic problem 62 9(20.5%) 2(11.1%) 0.316 60 7(15.2%) 3(21.4%) 0.426 11(17.7%)
Memory problem 62 9(20.5%) 2(11.1%) 0.316 60 8(17.4%) 3(21.4%) 0.502 11(17.7)
Dementia/cognitive decline 62 4(9.1%) 2(11.1%) 0.567 60 4(8.7%) 1(7.1%) 0.669 6 (9.7%)
Kidney Problem 62 5(11.4%) 2(11.1%) 0.674 60 6(13.0%) 1(7.1%) 0.478 7(11.3%)
Respiratory Problem 62 4(9.1%) 2(11.1%) 0.567 60 4(8.7%) 1(7.1%) 0.669 6(9.7%)
Swallowing Problem 62 4(9.1%) 0 0.243 60 2 (4.3%) 1(7.1%) 0.556 4(6.5%)
Diabetes 62 3(6.8%) 1(5.6%) 0.671 60 3(6.5%) 1(7.1%) 0.665 4(6.5%)
Thyroid problems 62 3(6.8%) 1(5.6%) 0.671 60 3(6.5%) 1(7.1)0 0.665 4(6.5%)
Cancer 62 2 (4.5%) 0 0.500 60 0 1(7.15) 0.233 2(3.2%)
  1. • Percentage within sexa and DNA statusb
  2. • # n = 52, male = 36, female = 16 ; $ n = 51, full = 40, mosaic = 11