From: Regional cortical volumes and congenital heart disease: a MRI study in 22q11.2 deletion syndrome
 |  | Control | 22q11DS | F | p |
---|---|---|---|---|---|
 | Total cerebral volumea | 1,072,287 (101,804) | 939,831 (114,254) | 52.7 | <0.001 |
Cortical regions showing relative preservation in 22q11DS | |||||
  Left | Lateral orbitofrontal | 8,227.3 (983.6) | 8,055.4 (1,162.2) | 20.4 | <0.001 |
Pars opercularis | 5,176.7 (925.3) | 5,242.4 (984.8) | 6.0 | 0.016 | |
Precentral | 14,684.5 (1,575.4) | 14,188.6 (1,841.1) | 5.7 | 0.019 | |
Pars orbitalis | 2,743.0 (456.8) | 2,628.7 (591.3) | 5.7 | 0.019 | |
Superior frontal | 27,430.5 (3,653.1) | 25,494.9 (3,990.5) | 4.8 | 0.030 | |
Medial orbitofrontal | 5,106.4 (880.8) | 4,955.8 (787.7) | 4.3 | 0.041 | |
  Right | Precentral | 14,493.0 (1,806.5) | 14,117.5 (2,006.4) | 15.0 | <0.001 |
Superior frontal | 25,605.5 (3,313.5) | 24,819.5 (3,713.7) | 13.5 | <0.001 | |
Lateral orbitofrontal | 8,273.2 (954.5) | 7,901.0 (1,381.6) | 12.2 | <0.001 | |
Pars orbitalis | 3,196.3 (630.0) | 3,097.5 (659.3) | 5.3 | 0.023 | |
Cortical regions showing disproportionate reductions in 22q11DS | |||||
  Left | Precuneus | 11,187.8 (1,633.8) | 9,164.4 (1,705.3) | 23.3 | <0.001 |
Fusiform | 10,379.1 (1,443.6) | 8,413.5 (1,534.4) | 16.8 | <0.001 | |
Rostral ant. cingulate | 2,701.1 (600.7) | 2,025.7 (471.3) | 12.7 | <0.001 | |
Temporal pole | 2,672.6 (500.4) | 2,278.3 (419.0) | 11.4 | <0.001 | |
Cuneus | 3,356.7 (686.1) | 2,636.8 (536.5) | 9.4 | 0.003 | |
Superior parietal | 14,728.9 (2,562.2) | 12,750.4 (2,058.1) | 7.3 | 0.008 | |
Caudal ant. cingulate | 2,031.5 (583.1) | 1,567.9 (315.5) | 6.8 | 0.010 | |
Pericalcarine | 2,258.7 (514.7) | 1,754.0 (426.1) | 4.2 | 0.041 | |
  Right | Precuneus | 11,452.6 (1,967.0) | 9,418.3 (1,472.7) | 19.6 | <0.001 |
Lingual | 7,545.5 (1,292.4) | 6,122.9 (954.0) | 13.5 | <0.001 | |
Rostral ant. cingulate | 2,123.5 (430.2) | 1,658.0 (383.2) | 13.4 | <0.001 | |
Fusiform | 9,628.3 (1,430.3) | 7,628.4 (1,732.7) | 11.8 | <0.001 | |
Cuneus | 3,860.5 (791.1) | 3,118.3 (672.2) | 5.8 | 0.017 | |
Rostral middle frontal | 20,440.6 (3,307.4) | 17,679.1 (2,576.0) | 4.9 | 0.028 | |
Temporal pole | 2,572.04 (574.1) | 2,178.6 (394.6) | 4.8 | 0.030 | |
Caudal ant. cingulate | 2,450.1 (679.0) | 1,943.9 (434.3) | 4.8 | 0.030 | |
Lateral occipital | 14,206.3 (2,243.5) | 12,217.8 (1,992.1) | 4.8 | 0.031 | |
Superior parietal | 14,360.8 (2,222.5) | 12,688.9 (1,956.1) | 4.5 | 0.036 | |
Pericalcarine | 2,593.0 (602.1) | 2,054.7 (417.9) | 4.0 | 0.049 |