Journal of Neurodevelopmental Disorders

Table 3 Statistical significance of regional cortical volume differences in the three-groups comparison

From: Regional cortical volumes and congenital heart disease: a MRI study in 22q11.2 deletion syndrome

		MANCOVA		Post hoc (Scheffe test)
		F	p	Ctl vs noCHD	Ctl vs CHD	noCHD vs CHD
	Cerebrum	31.5	<0.001	0.009	<0.001	0.001
Left	Precuneus	13.4	<0.001	<0.001	<0.001	0.031
	Lateral orbitofrontal	10.8	<0.001	0.278	0.036	0.003
	Fusiform	7.6	0.001	<0.001	<0.001	0.120
	Rostral ant. cingulate	5.9	0.003	<0.001	<0.001	0.165
	Cuneus	4.8	0.010	0.001	<0.001	0.097
	Parahippocampal	4.7	0.010	0.399	<0.001	0.001
	Superior parietal	3.9	0.022	0.010	<0.001	0.037
	Superior frontal	3.4	0.035	0.978	<0.001	0.001
	Precentral	3.3	0.041	0.075	0.037	0.077
Right	Precuneus	10.3	<0.001	<0.001	<0.001	0.012
	Precentral	7.7	0.001	0.419	0.011	0.002
	Superior frontal	6.5	0.002	0.720	0.008	0.006
	Rostral ant. cingulate	6.5	0.002	0.001	<0.001	0.033
	Lateral orbitofrontal	6.4	0.002	0.994	0.013	0.046
	Fusiform	6.2	0.003	0.002	<0.001	0.001
	Lingual	5.5	0.005	0.001	<0.001	0.089
	Superior parietal	3.1	0.049	0.030	<0.001	0.012
	Middle temporal	3.1	0.050	0.967	<0.001	0.002

Cortical regions that showed significant difference in the three-condition fixed-factor MANCOVA were further tested for differences 2×2 using a Scheffe test on the cortical volumes residualized for age. The whole MANCOVA was highly significant in both hemispheres (left: F_{62, 196} = 2.803; right: F_{62, 196} = 2.268). The most significant regions (p < 0.0016) are highlighted in bold and further illustrated in Fig. 2.

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ISSN: 1866-1955

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