Fig. 2

Classes of potential overlap in synaptic mechanisms between ASD genes/proteins and pathways involved in FXS: (1) proteins involved in other forms of ASD may be in the signaling cascade for activation of FMRP-regulated translation; (2) FMRP may directly regulate proteins involved in different forms of ASD; and (3) convergence of glutamate and GABA pathway defects in FXS and ASD due to dysregulation of proteins generally important in maintaining inhibitory/excitatory balance and balance of activity in brain glutamate and GABA systems