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Table 3 Replication results for 6 SNPs with significant marginal effects

From: Glutathione pathway gene variation and risk of autism spectrum disorders

SNP (gene) Primary analysis (n = 1,149) Independent AGRE families Combined
  Genotype OR (95% CI) P value OR (95% CI) Sample size (n) P value P valueb
rs12737233 (CTH) C/TT/T 0.91 (0.65, 1.28) 4.83 (1.85, 12.59) 0.002 1.02 (0.81,1.29) 0.62 (0.31, 1.23) 3,327 0.30 0.84
rs7658602 (PGDS) G/TT/T 0.27 (0.10, 0.78) 0.20 (0.07, 0.60) 0.01 0.71 (0.20, 2.49) 0.77 (0.22, 2.76) 3,327 0.73 0.06
rs761141 (GCLC) C/TT/T 2.10 (1.20, 3.69) 1.67 (0.91, 3.09) 0.02 1.10 (0.70, 1.71) 1.34 (0.85, 2.13) 3,327 0.10 0.11
rs524553 (GCLC)a C/TT/T 2.70 (1.47, 4.98) 2.23 (1.16, 4.28) 0.003 1.22(0.81, 1.83) 1.46 (0.94, 2.28) 3,327 0.08 n/ac
rs1230155 (ADH5) A/GG/G 0.70 (0.54, 0.89) 0.69 (0.44, 1.07) 0.02 0.92 (0.76, 1.11) 0.74 (0.52, 1.03) 3,327 0.20 0.08
rs11017128 (GLRX3) A/GG/G 0.69 (0.51, 0.93) 0.78 (0.36, 1.70) 0.04 0.90 (0.74, 1.10) 0.91 (0.49, 1.69) 2,858 0.59 0.09
  1. aReplication of SNP rs524553 assessed through a proxy (rs2066511) with r2 = 0.9
  2. bIdentical methods were used to calculate p value with combined data set including the primary analysis and independent families.
  3. cDid not combine p values since replication analysis used proxy SNP