From: Glutathione pathway gene variation and risk of autism spectrum disorders
SNP (gene) | Primary analysis (n = 1,149) | Independent AGRE families | Combined | ||||
---|---|---|---|---|---|---|---|
Genotype | OR (95% CI) | P value | OR (95% CI) | Sample size (n) | P value | P valueb | |
rs12737233 (CTH) | C/TT/T | 0.91 (0.65, 1.28) 4.83 (1.85, 12.59) | 0.002 | 1.02 (0.81,1.29) 0.62 (0.31, 1.23) | 3,327 | 0.30 | 0.84 |
rs7658602 (PGDS) | G/TT/T | 0.27 (0.10, 0.78) 0.20 (0.07, 0.60) | 0.01 | 0.71 (0.20, 2.49) 0.77 (0.22, 2.76) | 3,327 | 0.73 | 0.06 |
rs761141 (GCLC) | C/TT/T | 2.10 (1.20, 3.69) 1.67 (0.91, 3.09) | 0.02 | 1.10 (0.70, 1.71) 1.34 (0.85, 2.13) | 3,327 | 0.10 | 0.11 |
rs524553 (GCLC)a | C/TT/T | 2.70 (1.47, 4.98) 2.23 (1.16, 4.28) | 0.003 | 1.22(0.81, 1.83) 1.46 (0.94, 2.28) | 3,327 | 0.08 | n/ac |
rs1230155 (ADH5) | A/GG/G | 0.70 (0.54, 0.89) 0.69 (0.44, 1.07) | 0.02 | 0.92 (0.76, 1.11) 0.74 (0.52, 1.03) | 3,327 | 0.20 | 0.08 |
rs11017128 (GLRX3) | A/GG/G | 0.69 (0.51, 0.93) 0.78 (0.36, 1.70) | 0.04 | 0.90 (0.74, 1.10) 0.91 (0.49, 1.69) | 2,858 | 0.59 | 0.09 |