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Table 3 Replication results for 6 SNPs with significant marginal effects

From: Glutathione pathway gene variation and risk of autism spectrum disorders

SNP (gene)

Primary analysis (n = 1,149)

Independent AGRE families

Combined

 

Genotype

OR (95% CI)

P value

OR (95% CI)

Sample size (n)

P value

P valueb

rs12737233 (CTH)

C/TT/T

0.91 (0.65, 1.28) 4.83 (1.85, 12.59)

0.002

1.02 (0.81,1.29) 0.62 (0.31, 1.23)

3,327

0.30

0.84

rs7658602 (PGDS)

G/TT/T

0.27 (0.10, 0.78) 0.20 (0.07, 0.60)

0.01

0.71 (0.20, 2.49) 0.77 (0.22, 2.76)

3,327

0.73

0.06

rs761141 (GCLC)

C/TT/T

2.10 (1.20, 3.69) 1.67 (0.91, 3.09)

0.02

1.10 (0.70, 1.71) 1.34 (0.85, 2.13)

3,327

0.10

0.11

rs524553 (GCLC)a

C/TT/T

2.70 (1.47, 4.98) 2.23 (1.16, 4.28)

0.003

1.22(0.81, 1.83) 1.46 (0.94, 2.28)

3,327

0.08

n/ac

rs1230155 (ADH5)

A/GG/G

0.70 (0.54, 0.89) 0.69 (0.44, 1.07)

0.02

0.92 (0.76, 1.11) 0.74 (0.52, 1.03)

3,327

0.20

0.08

rs11017128 (GLRX3)

A/GG/G

0.69 (0.51, 0.93) 0.78 (0.36, 1.70)

0.04

0.90 (0.74, 1.10) 0.91 (0.49, 1.69)

2,858

0.59

0.09

  1. aReplication of SNP rs524553 assessed through a proxy (rs2066511) with r2 = 0.9
  2. bIdentical methods were used to calculate p value with combined data set including the primary analysis and independent families.
  3. cDid not combine p values since replication analysis used proxy SNP