Fig. 3
From: Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders
Regulation of the FMRP-CYFIP1-eIF4E complex. FMRP (green) binds the mRNAs in a BC1-dependent or independent manner and anchors them to CYFIP1 (violet). CYFIP1 binds eIF4E (blue), preventing the formation of active translational initiation complexes. Upon synaptic stimuli, i.e., activation of the TrkB (BDNF) or mGluR (DHPG) receptors, CYFIP1 and FMRP are released from eIF4E, which then binds eIF4G allowing protein synthesis to occur