From: Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders
FMRP Function | Regulation | Target MRNAS | Where FMRP affects their regulation | How FMRP affects their regulation | References |
---|---|---|---|---|---|
Stability | + | PSD-95 | Mouse hippocampus | Activity-dependent | Zalfa et al. 2007 |
+ | GABA subunits | Mouse cortex; Drosophila. | mRNA levels are reduced but a direct evidence on their different stability is not available | Gantois et al. 2006; D’Hulst et al. 2006; Dictenberg et al. 2008 | |
Transport | + | Map1B | Primary hippocampal neurons | Activity-driven transport | Dictenberg et al. 2008 |
+ | α-CaMKII | Primary hippocampal neuron | Activity-driven transport | ||
+ | Sapap4 | Primary hippocampal neurons | Activity-driven transport | Dictenberg et al. 2008 | |
+ | Rgs5 | Hippocampal slices | Basal mRNA localization | Miyashiro et al. 2003 | |
Translation | − | Map1B | Mouse brain and hippocampal slices; human FXS lymphoblastoid cells; | Basal and activity-dependent | Brown et al. 2001; Zalfa et al. 2003; Lu et al. 2004; Hou et al. 2006 |
− | Arc | Mouse brain; hippocampal slices; synaptoneurosomes | Basal and activity-dependent | ||
− | α-CaMKII | Mouse brain; hippocampal slices; synaptoneurosomes | Basal and activity-dependent | Zalfa et al. 2003; Hou et al. 2006; Muddashetty et al. 2007; Kao et al. 2010 | |
− | App | Cortical synaptoneurosomes | Basal and activity-dependent; antagonistic effects with HnRNPC | ||
− | PSD-95 | Cortical synaptoneurosomes | Activity-dependent |