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Table 2 Multivariable-adjusted (adjusted for all other variables in the table and further adjusted for gender, race, and ethnicity) mixed effects modeling analyses for standard scores of the Comprehensive Assessment of Spoken Language acquired after 4–5 years of experience with cochlear implant among 116 young children with congenital hearing loss in the CDaCI study

From: Language development after cochlear implantation: an epigenetic model

Baseline factors associated with change in standard scores

Estimate

Standard error

P value

95% Confidence interval

Antonyms (vocabulary)

With measurable spoken language development at baselinea (N = 20)

94.58

3.76

0.0020b

87.12

102.05

CI activated <18 months of age (N = 34)

86.67

2.83

0.00521b

81.07

92.28

CI activated ≥18 months of age (N = 62)

80.15

2.15

(Reference)

75.88

84.42

Maternal sensitivity, per point increase

8.63

2.16

0.0001

4.35

12.93

Family income, less than $50,000 per year

−8.44

2.92

0.0047

−14.23

−2.64

Syntax construction (expression)

With measurable spoken language development at baselinea (N = 20)

87.71

4.67

<0.0001b

78.45

96.97

CI activated <18 months of age (N = 34)

83.43

3.30

<0.0001b

76.89

89.97

CI activated ≥18 months of age (N = 62)

63.42

2.61

(Reference)

58.24

68.60

Maternal sensitivity, per point increase

10.23

2.59

0.0001

5.11

15.36

Family income, less than $50,000 per year

−4.62

3.48

0.1873

−11.53

2.28

Syntax comprehension (reception)

With measurable spoken language development at baselinea (N = 20)

97.41

3.76

0.0006b

89.96

104.86

CI activated <18 months of age (N = 34)

96.84

3.59

0.0005b

89.72

103.96

CI activated ≥18 months of age (N = 62)

80.41

2.93

(Reference)

74.61

86.22

Maternal sensitivity, per point increase

11.34

2.36

<0.0001

6.67

16.01

Family income, less than $50,000 per year

−3.89

4.00

0.3332

−11.81

4.04

Pragmatic judgment (pragmatics)

With measurable spoken language development at baselinea (N = 20)

84.33

4.32

0.0030b

75.76

92.90

CI activated <18 months of age (N = 34)

89.67

2.60

<0.0001b

84.51

94.82

CI activated ≥18 months of age (N = 62)

69.66

2.33

(Reference)

65.05

74.28

Maternal sensitivity, per point increase

11.01

2.09

<0.0001

6.88

15.15

Family income, less than $50,000 per year

−5.37

3.11

0.0868

−11.53

0.79

Core composite

With measurable spoken language development at baselinea (N = 20)

90.21

4.37

0.0005b

81.54

98.88

CI activated <18 months of age (N = 34)

86.66

3.15

0.0003b

80.41

92.90

CI activated ≥18 months of age (N = 62)

71.83

2.61

(Reference)

66.65

77.00

Maternal sensitivity, per point increase

11.64

2.31

<0.0001

7.06

16.22

Family income, less than $50,000 per year

−7.38

3.52

0.0384

−14.36

−0.40

  1. aComprehension or expression standard score from the Reynell Developmental Language Scales (RDLS) ≥70 at baseline
  2. bCompared to children with CI activated at 18 months of age or older