Figure 3

ASD trustees show diminished cingulate self-response pattern during social exchange in the multi-round trust game (adapted from [[46]]). (A) Diminished cingulate response pattern during ‘self–phase’ of the iterated multi-round trust game. The ‘other’ response pattern was similar in ASD (n = 12) and age- and IQ-matched control participants (n = 18). However the cingulate ‘self’ response was diminished in the ASD cohort. Projection of the BOLD response pattern onto the cingulate self-eigenmode reveals the contribution of that mode of operation in the cingulate, and show that it is significantly diminished in the ASD cingulate cortex. (B) Regions in the middle cingulate cortex show diminished response, which correlates with ASD symptom severity. The middle regions of the cingulate cortex show significant correlation with symptom severity in the ASD cohort. The less active this region is during the self-phase is correlated with the communication subscale, social subscale, and overall score on the Autism Diagnostic Interview, Revised (open circles: ADI-R communication subscale, r = −0.69, p = −0.012; light blue filled circles: ADI-R social subscale, r = −0.70, p = 0.011; dark blue filled circles: ADI-R total score, r = −0.73, p = 0.007).