Spatial distribution of striatal interneurons. (A) Voronoi tessellation of two representative sections of the caudate nucleus from an ethanol-treated and a control case. Bar = 250 μm. (B) Frequency distribution of the Voronoi polygon areas in ethanol-treated and control cases. Polygon areas larger than 60,000 μm2 were excluded from the quantitative analysis. Bins = 3,000 μm2. (C) Mean and standard deviation of the polygon areas for each of the studied ethanol-treated and control cases (four sections per case). (D) Mean coefficient of variation, calculated as the ratio between the standard deviation and the mean of polygon areas. (E) Packing density of labeled neurons, total volume of caudate nucleus (from the rostral pole to the appearance of globus pallidus), and total number of labeled neurons in the caudate.