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Table 3 Structural connectivity MRI studies on working memory in high-functioning adolescents with ASD

From: Working memory deficits in high-functioning adolescents with autism spectrum disorders: neuropsychological and neuroimaging correlates

Study Mean age in years (SD) Participant groups General IQ (SD) Method Results
Location Fractional anisotropy Mean diffusivity
Barnea-Goraly et al. (2004) [91] 14.6 (3.4) (n = 7) HFA 101 (12.2) Whole-brain voxel-based analysis Ventromedial prefrontal cortices, anterior cingulate gyri, temporoparietal junctions NR
13.4 (2.8) (n = 9) TYP 107 (8.5)
Cheng et al. (2010) [94] 13.7 (2.5) (n = 25) ASD 101.6 (18.9) Whole-brain voxel-based analysis Right posterior limb of internal capsule NR
Frontal lobe, right cingulate gyrus, bilateral insula, right superior temporal gyrus, bilateral middle cerebellar peduncle
13.5 (2.2) (n = 25) TYP 109.0 (9.5)  
Groen et al. (2011) [90] 14.4 (1.6) (n = 17) ASD 98 (18) Whole-brain voxel-based analysis Cerebrum, cerebellum =
15.5 (1.8) (n = 25) TYP 105 (9)
Shukla et al. (2011) [92] 12.6 (0.6) (n = 26) Autism, AS 106.0 (3.6) Whole-brain voxel-based analysis Corpus callosum, anterior and posterior limbs of internal capsule, inferior longitudinal, inferior fronto-occipital, and superior longitudinal fasciculus cingulum, anterior thalamic radiation, corticospinal tract
13.0 (0.6) (n = 24) TYP 108.2 (2.6)
Shukla et al. (2011) [93] 12.6 (0.6) (n = 26) Autism, AS 106.0 (3.6) Whole-brain voxel-based analysis Frontal lobe
Temporal lobes, parietal lobes
  13.0 (0.6) (n = 24) TYP 108.2 (2.6)    =
  1. AS: Asperger syndrome; ASD: Autism spectrum disorders; HFA: high-functioning autism; NR: not recorded; TYP: typical development.
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