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Table 4 Results of analysis of covariance (ANCOVA) for local gyrification index in gyral regions

From: Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalities

Gyral region

Hemisphere

Local gyrification index

  

F

P value

DoD

Frontal lobe

Superior frontal

L

12.315

0.002 b

-

R

11.938

0.002 b

-

Caudal middle frontal

L

1.074

0.310

 

R

5.046

0.034 a

-

Rostral middle frontal

L

4.036

0.055

 

R

1.870

0.184

 

Pars opercularis

L

7.575

0.011 a

-

R

4.071

0.054

 

Pars triangularis

L

3.860

0.061

 

R

2.009

0.169

 

Pars orbitalis

L

8.324

0.008 a

-

R

4.869

0.037 a

-

Lateral orbitofrontal

L

7.702

0.010 a

-

R

1.797

0.192

 

Medial orbitofrontal

L

6.298

0.019 a

-

R

4.472

0.045

-

Precentral

L

5.693

0.025 a

-

R

6.354

0.018 a

-

Paracentral

L

5.165

0.032 a

-

R

2.847

0.104

 

Frontal pole

L

6.768

0.015 a

-

R

1.366

0.253

 

Temporal lobe

Superior temporal

L

11.052

0.003 b

-

R

24.242

<0.001 b

-

Middle temporal

L

5.876

0.023 a

-

R

18.742

<0.001 b

-

Inferior temporal

L

0.312

0.582

 

R

4.855

0.037 a

-

Entorhinal

L

2.504

0.126

 

R

6.935

0.014 a

-

Fusiform

L

0.044

0.836

 

R

1.095

0.305

 

Parahippocampal

L

0.013

0.911

 

R

0.529

0.474

 

Temporal pole

L

3.399

0.077

 

R

5.442

0.028 a

-

Transverse temporal

L

3.517

0.072

 

R

14.003

0.001 b

-

Banks superior temporal sulcus

L

0.190

0.667

 

R

5.689

0.025 a

-

Parietal lobe

Superior parietal

L

1.640

0.212

 

R

0.125

0.727

 

Inferior parietal

L

0.220

0.643

 

R

1.463

0.238

 

Supramarginal

L

2.117

0.158

 

R

5.233

0.031 a

-

Postcentral

L

6.597

0.017 a

-

R

9.344

0.005 a

-

Precuneus

L

3.117

0.090

 

R

3.762

0.064

 

Occipital lobe

Lateral occipital

L

0.719

0.405

 

R

0.498

0.487

 

Lingual

L

0.253

0.620

 

R

2.862

0.103

 

Cuneus

L

3.589

0.070

 

R

4.317

0.048

-

Pericalcarine

L

1.915

0.179

 

R

5.044

0.034 a

-

Rostral anterior cingulate

L

4.848

0.037 a

-

R

5.487

0.027 a

-

Caudal anterior cingulate

L

6.789

0.015 a

-

R

3.213

0.085

 

Posterior cingulate

L

2.052

0.164

 

R

3.165

0.087

 

Isthmus cingulate

L

0.213

0.648

 

R

2.808

0.106

 

Insula

L

7.013

0.014 a

-

 

R

5.616

0.026 a

-

  1. Bold represents significant results (P <0.05).
  2. a and bRepresent significant results after correction for multiple comparisons with false discovery rate (FDR), a(q = 0.1) and b (q = 0.05 or 0.1). Minus indicates the direction of the group difference, - = NF1 < typically developing subjects.
  3. DoD = direction of difference; L = left; R = right.
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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