Table 2 Global brain volumes in children with PWS and healthy controls

TIV (mm³)

1,234,546

107,087

133,1869

128,966

1,410,393

98,231

0.007 (0.02)

0.005

ns

ns

Total GM (mm³)

684,884

59,560

754,819

74,391

788,263

67,474

0.008 (0.02)

0.007

ns

0.118

Cortical GM (mm³)

511,270

53,409

563,276

65,484

588,374

60,604

0.026 (0.047)

0.026

ns

ns

Subcortical GM (mm³)

173,615

12,739

191,543

11,495

199,890

2,525

<0.001 (0.001)

<0.0001

ns

0.036

Total WM (mm³)

408,399

45,050

413,740

60,537

462,809

38,073

0.034 (0.053)

0.061

0.098

ns

Total CC (mm³)

3,053

345

2,784

533

3,010

342

ns (ns)

ns

ns

ns

Brainstem (mm³)

16,207

1,378

17,384

1,511

20,493

1,858

<0.001 (0.001)

<0.0001

0.016

ns

Ventricles (mm³)

Lateral (mm³)

14,318

11,606

20,598

8,781

9,244

610

0.001 (0.004)

ns

0.006

ns

Third (mm³)

932

433

1,091

275

868

190

ns (ns)

ns

ns

ns

Fourth (mm³)

1,986

495

1,952

394

1,853

455

ns (ns)

ns

ns

ns

Cerebellum (mm³)

124,737

11,456

141,378

9,644

146,092

11,022

0.001 (0.004)

0.001

ns

0.042

Surface CSF (mm³)

1,199

395

1,469

253

1,077

255

0.027 (0.047)

ns

0.029

0.133

Mean cortical thickness (mm)

2.77

0.104

2.89

0.185

2.8

0.106

0.066 (0.08)

Mean pial cortical area (mm²)

221,117

22,519

232,867

20,785

249,491

23,373

0.05 (0.07)