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Table 2 Significant gene ontology (GO) categories and molecular functions annotations for genes differentially expressed in the brain of adult (P60) mice neurodevelopmentally exposed to ethanol

From: Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure

Timing of treatmenta

GO category

Functions annotation

P value

Molecules

E 8/11

Cellular assembly and organization

Extension of axons

0.0082

Dclk1, Ntf3, Tnfrsf12a

 

Protein synthesis

Translation of protein

0.0025

Eif2s1, Hspa5

 

Cell-to-cell signaling and interaction

Synaptic transmission

0.0136

Egr3, Ntf3

 

Tissue development

Accumulation of cells

0.0153

Cdkn1a, Ntf3

 

Cell death

Cell death of sensory neurons

0.0171

Hsf1, Ntf3

 

Tissue morphology

Quantity of interneurons

0.0250

Dclk1, Ntf3

E 14/16

Cellular movement

Migration of interneurons

0.00013

Dcx, Dlx1, Dlx2

 

Tissue development

Development of olfactory bulb

0.0168

Dlx2, Nr2e1

 

Cellular development

Differentiation of neuronal progenitor cells

0.0214

Dlx1, Dlx2

 

Cell death

Cell death of sensory neurons

0.0238

Bok, Hsf1

 

Neurological disease

Neurodegenerative disorder

0.0458

Cav1, Cox1, Dcx, Htr6, Pcna

 

Cell morphology

Shape change of neurons

0.0473

Dcx, Hcrt

P 4/7

Cell-to-cell signaling and interaction

Synaptic transmission

0.00014

Apoe, Chrm1, Cnr1, Ephb2, Grik1, Grin2b, Htr1a, Nrgn1, Ntf3

 

Lipid metabolism

Secretion of steroid

0.0018

Apoe, Pomc

 

Cell-to-cell signaling and interaction

Synaptic depression

0.0133

Chrm1, Cnr1, Ephb1, Grin2b, Htt

 

Cell-to-cell signaling and interaction

Plasticity of synapse

0.0144

Apoe, Grik1, Grin2b, Htt, Inppl1, Syngap1

 

Cell morphology

Formation of cellular protrusions

0.0329

Apoe, Dst, Efna5, Efnb2, Egfr, Ephb1, Grm4, Htt, Kif23, Nbl1, Ntf3, Ntng2, Pcdh15, Rhog, Syne1, Syngap1, Wnt3a

 

Cellular development

Proliferation of neuronal cells

0.0366

Cnr1, Irx5, Mycn, Nbn, Ntf3, Wnt3a

 

Neurological disease

Gliosis of hippocampus

0.0400

Apoe, Htt

  1. aE, embryonic day; P, postnatal day.