Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure

Table 3 Ingenuity® canonical pathways significantly associated with genes altered in the adult (P60) brain by neurodevelopmental alcohol exposure

Timing of treatment^a	Ingenuity® canonical pathway	P value	Molecules
E 8/11	Endoplasmic reticulum stress pathway	0.00003	Xbp1, Dnajc3, Eif2s1, Hspa5
	Xenobiotic metabolism signaling	0.00282	Sra1, Ftl, Nras, Map3k13, Camk1g, Cyp2c19, Ncor2, Mapk11
	Glucocorticoid receptor signaling	0.00501	Sra1, Nras, Hpsa1a, Taf5l, Cdkn1a, Ncor2, Hspa5, Mapk11
	Phospholipase C signaling	0.00741	Rhog, Nras, Mef2d, Myl4, Gng13, Rapgef3, Itga4
	Antiproliferative role of somatostatin receptor 2	0.0263	Nras, Cdkn1a, Gng13
	Calcium signaling	0.0269	Calr, Mef2d, Trdn, Camk1g, Myl4
E 14/16	Fatty acid biosynthesis	0.00363	Oxsm, Mcat
	Serotonin receptor signaling	0.00603	Htr5a, Htr3a, Htr6
	Regulation of actin-based motility by Rho	0.0145	Myl9, Rhog, Rnd3, Ppp1r12b
P 4/7	Glutamate receptor signaling	0.000007	Grin2b, Grin3b, Gnb3, Grid1, Grin2c, Grin2d, Grik3, Grm4, Grik1
	Retinoic acid-mediated apoptosis signaling	0.00055	Fadd, Casp3, Rarb, Tnfsf10, Rxrb, Irf1
	Ephrin receptor signaling	0.00224	Frin2b, Efnb2, Ephb1, Grin3b, Gnb3, Itsn1, Grin2c, Efna5, Grin2d, Vegfc, Figf
	Circadian rhythm signaling	0.00692	Grin2b, Grin 3b, Grin2c, ,Grin2d
	One carbon pool by folate	0.00794	Tyms, Mthfs, Mtr
	mTOR signaling	0.0288	Fau, Rhog, Rps10, Rptor, Vegfc, Figf, Insr, Rpsa

ISSN: 1866-1955