Associations of HLA alleles with specific language impairment

Table 2 Results of the quantitative transmission disequilibrium test analyses

HLA allele	General QTDT	Maternal parent-of-origin analysis	Paternal parent-of-origin analysis
HLA-A A1	0.004 (NWR)+^a 0.026 (ELS)+
HLA-A A3	0.006 (ELS)−^a
HLA-B B8		0.021 (RLS)−^a	0.013 (RLS)+^a
HLA-C Cw6			0.019 (ELS)−^a
HLA-C Cw8	0.039 (ELS)+^a
DQA1*0301			0.03 (ELS)− 0.011 (RLS)−^a
DQA1*0501		0.034 (RLS)−^a	0.029 (RLS)+
DRB1 DR7	0.019 (RLS)+
DRB1 DR17		0.028 (RLS)−

Associations with P ≤0.05 are shown. The + and − symbols indicate the direction of the association, and the associated trait is listed next to the P value. ^aAssociations with empirical P ≤0.05 in the permutation analyses. ELS, expressive language score; NWR, nonword repetition; QTDT, quantitative transmission disequilibrium test; RLS, receptive language score.

ISSN: 1866-1955