Associations of HLA alleles with specific language impairment

Table 3 Results of the case-control association analysis

HLA allele	Number of alleles counted in probands	Number of alleles counted in controls	Frequency in probands	Frequency in controls	Fisher’s exact test P	Relative risk	95% confidence interval – lower boundary	95% confidence interval – upper boundary	Effect
HLA-DRB1 DR10	395	912	0.018	0.002	0.004	2.575	1.773	3.737	Risk
HLA-DQA1*0301	453	1078	0.174	0.231	0.012	0.753	0.59	0.961	Protective
HLA-B B57	443	1055	0.023	0.047	0.029	0.541	0.303	0.963	Protective
HLA-DRB1 DR4	395	912	0.108	0.158	0.02	0.692	0.510	0.939	Protective
HLA-DRB1 DR12*	395	912	0.005	0.02	0.05	0.333	0.09	1.243	Protective

Associations with P ≤0.05 are shown. ^aThe P value for DR12 was 0.050339 but was included here since the P values were rounded up to the third decimal place.

ISSN: 1866-1955