Figure 4
From: The multiple molecular facets of fragile X-associated tremor/ataxia syndrome
Mechanisms that may contribute to fragile X-associated tremor/ataxia (FXTAS) pathology. Expression of FMR1 mRNA and associated antisense transcripts are increased inpremutation carriers. Some transcripts accumulate in the nucleus and recruit various RNA binding proteins, while export and non-AUG translation results in production of polyglycine-containing or polyalanine-containing proteins.