Table 2 PIF ranking and effect on neurotrophic gene expression in HESC
Axonal guidance signaling 9.20E - 02 | Neuregulin signaling 8.70E - 02 | Synaptic long-term potentiation 7.46E - 02 | Amyotrophic lateral sclerosis signaling 6.94E - 02 | Synaptic long-term depression 4.84E - 02 | Huntington’s disease signaling 4.90E - 02 | Oxidative phosphorylation 3.47E - 02 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CDC42 | 3.7 | PTEN | 2.6 | CAMK2B | 2 | RAB5A | 3.9 | PRKG1 | -2.5 | CREBBP | -2.1 | ATP6V0D2 | 3.5 |
EPHA5 | 2.3 | ERBB2IP | -2.2 | CAMK2D | -2.1 | GRIK5 | 2.3 | PRKCB1 | -4.4 | PIK3CA | -2.4 | PPA2 | 3.5 |
SEMA4C | 2 | PDK1 | -3 | CREBBP | -2.1 | GRIK2 | -2 | GRM1 | -17 | HDAC9 | -3.7 | CYB5A | 3.1 |
PDGFC | -2.5 | ERBB3 | -3.2 | PRKCB1 | -4.4 | PIK3CA | -2.4 | Â | Â | CASP8 | -4.2 | NDUFA10 | 2.1 |
SEMA6A | -4.5 | PRKCB1 | -4.4 | GRM1 | -17 | BCL2 | -21 | Â | Â | PRKCB1 | -4.4 | NDUFA5 | -2.1 |
SEMA4D | -6 | AKT2 | -5.6 | Â | Â | Â | Â | Â | Â | AKT2 | -5.6 | Â | Â |
SEMA3D | -10 | Â | Â | Â | Â | Â | Â | Â | Â | GRM1 | -17 | Â | Â |
SEMA3C | -11 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |