Table 5 Summary of enrichment analysis for HESC and FTDC (genes that are expressed more than twofold or decreased twofold) regulating processes following PIF treatment
| Â | HESC | FTDC | ||
|---|---|---|---|---|
Ontology | Upregulated processes | Downregulated processes | Upregulated processes | Downregulated processes |
GeneGo Pathway Maps | G-protein signaling_RhoB regulation pathway | Development_TGF-beta-dependent induction of EMT via MAPK | Cell cycle_role of 14-3-3 proteins in cell cycle regulation | Androstenedione and testosterone biosynthesis and metabolism p.2 |
| Â | Development_angiotensin signaling via beta-Arrestin | Immune response_CD137 signaling in immune cell | Development_EGFR signaling via PIP3 | Acetaminophen metabolism |
| Â | G-protein signaling_RhoA regulation pathway | Development_regulation of epithelial-to-mesenchymal transition (EMT) | Apoptosis and survival_role of CDK5 in neuronal death and survival | 1-naphthylamine and 1-nitronaphthalene metabolism |
| Â | Immune response_antiviral actions of Interferons | Cell adhesion_role of tetraspanins in the integrin-mediated cell adhesion | Development_neurotrophin family signaling | Immune response_IL-15 signaling via JAK-STAT cascade |
| Â | Immune response_IFN alpha/beta signaling pathway | Development_beta-adrenergic receptors transactivation of EGFR | Neurophysiological process_receptor-mediated axon growth repulsion | 2-naphthylamine and 2-nitronaphthalene metabolism |
| Â | Development_signaling of beta-adrenergic receptors via beta-arrestins | Development_gastrin in differentiation of the gastric mucosa | Role of alpha-6/beta-4 integrins in carcinoma progression | Estradiol metabolism |
| Â | G-protein signaling_regulation of CDC42 activity | Neurophysiological process_receptor-mediated axon growth repulsion | Cell cycle_cell cycle (generic schema) | G-protein signaling_regulation of RAC1 activity |
| Â | Muscle contraction_GPCRs in the regulation of smooth muscle tone | Transcription_androgen receptor nuclear signaling | Development_ERK5 in cell proliferation and neuronal survival | Immune response_IL-15 signaling via JAK-STAT cascade |
| Â | Neurophysiological process_EphB receptors in dendritic spine morphogenesis and synaptogenesis | Regulation of metabolism_triiodothyronine and thyroxine signaling | Cell cycle_initiation of mitosis | Benzo [a] pyrene metabolism |
| Â | G-protein signaling_regulation of RAC1 activity | Cell adhesion_integrin-mediated cell adhesion and migration | G-protein signaling_K-RAS regulation pathway | Apoptosis and survival_HTR1A signaling |