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Table 6 PIF effect on FTDC analyzing maps, processes, disease ranking, and strength of association

From: PreImplantation factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor

GeneGo pathway maps

GeneGo process networks

GO processes

GeneGo diseases (by biomarker)

Name

p value

Name

p value

Name

p value

Name

p value

Acetaminophen metabolism

0.00001014

Reproduction_feeding and neurohormones signaling

0.0004425

Multicellular organismal process

2.563E - 14

Skin and connective tissue diseases

1.006E - 10

Androstenedione and testosterone biosynthesis and metabolism p.2

0.00003172

Development_blood vessel morphogenesis

0.003215

Regulation of biological quality

9.359E - 14

Skin diseases

1.014E - 09

Cell cycle_role of 14-3-3 proteins in cell cycle regulation

0.00003564

Muscle contraction

0.003752

Positive regulation of biological process

1.611E - 13

Neoplasms by histologic type

2.396E - 09

Androstenedione and testosterone biosynthesis and metabolism p.2/rodent version

0.0000375

Cell cycle_meiosis

0.00434

Regulation of multicellular organismal process

3.408E - 13

Myoepithelioma

1.598E - 08

Development_EGFR signaling via PIP3

0.00004489

Cell cycle_G2-M

0.005763

Regulation of localization

4.975E - 13

Neoplasms, glandular, and epithelial

2.089E - 08

Cell cycle_initiation of mitosis

0.00006886

Development_ossification and bone remodeling

0.007848

Regulation of secretion

8.326E - 13

Capillary leak syndrome

6.196E - 08

Development_prolactin receptor signaling

0.00007228

DNA damage_DBS repair

0.00865

Intracellular signaling cascade

1.943E - 12

Breast neoplasms

8.058E - 08

Apoptosis and survival_role of CDK5 in neuronal death and survival

0.0003167

Development_regulation of angiogenesis

0.01318

Cellular calcium ion homeostasis

2.698E - 12

Breast diseases

8.287E - 08

Estradiol metabolism

0.0003642

Reproduction_male sex differentiation

0.01432

Calcium ion homeostasis

4.215E - 12

Schizophrenia

1.035E - 07

G-protein signaling_regulation of RAC1 activity

0.0004169

Translation_regulation of initiation

0.0149

Cellular metal ion homeostasis

4.501E - 12

Connective tissue diseases

1.222E - 07