Table 8 Top biological process of Interactome Hub networks, associated with statistical significance and major genes involved in the process

Regulation of transcription, DNA-dependent

74.07

1.216E - 28

NKX3-1, SP3, SOX2, STAT3, ZFHX3

Response to chemical stimulus

69.84

4.365E - 24

Regulation of RNA metabolic process

74.07

3.141E - 28

Response to organic substance

57.14

4.814E - 24

UGT1A1, STAT3

Regulation of transcription from RNA polymerase II promoter

59.26

4.227E - 28

STAT3

Positive regulation of biological process

71.43

5.785E - 24

Positive regulation of gene expression

57.41

6.061E - 28

MDM2

Positive regulation of macromolecule metabolic process

50.79

2.78E - 21

Positive regulation of transcription

55.56

4.355E - 27

NKX3-1, SOX2, STAT3

Organ development

63.49

3.189E - 21

Transcription

74.07

1.364E - 26

NKX3-1, SP3, SOX2, STAT3, HIPK2, ZFHX3

Positive regulation of cellular process

65.08

3.603E - 21

Regulation of transcription

79.63

2.039E - 26

NKX3-1, SP3, SOX2, STAT3, HIPK2, ZFHX3

Positive regulation of cellular metabolic process

50.79

1.333E - 20

Positive regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process

55.56

1.925E - 25

Positive regulation of gene expression

42.86

4.074E - 20

CDK1

Positive regulation of transcription, DNA-dependent

50

3.096E - 25

HIPK2

Positive regulation of metabolic process

50.79

5.766E - 20

Positive regulation of RNA metabolic process

50

3.955E - 25

Response to stimulus

77.78

4.007E - 19

Positive regulation of macromolecule biosynthetic process

55.56

4.246E - 25

System development

66.67

4.06E - 19

Positive regulation of nitrogen compound metabolic process

55.56

5.851E - 25

Positive regulation of transcription, DNA-dependent

38.1

4.184E - 19

TP63, REL