Table 1 Demographic, MRI and ¹ H MRS characteristics by group

N = 85

n = 35

n = 11

n = 39

Demographics, mean (percent)

 Male no.

26 (74%)

6 (55%)

24 (62%)

p = 0.358^a

 Age, mean (SD)

35 (12)

52 (6)

35 (12)

p < 0.001^b

Cognitive measures

 CAMCOG (total) score

56 (22)

32 (21)

119 (3)

p < 0.001^b

 CAMCOG (short-term memory) score

12 (7)

5 (4)

22 (2)

p < 0.001^b

MRI VOI proportions

 Grey proportion (average R and L)

0.76 (0.07)

0.75 (0.11)

0.72 (0.08)

p = 0.187^b

 White proportion (average R and L)

0.24 (0.07)

0.25 (0.11)

0.28 (0.08)

p = 0.187^b

Mean CSF (R)

0.13 (0.07)

0.15 (0.04)

0.07 (0.04)

p = 0.000^b

Mean CSF (L)

0.10 (0.07)

0.17 (0.09)

0.07 (0.04)

p = 0.006^b

Mean metabolite concentration

 Glx (R hippocampus)

38.89 (6.13)

41.04 (4.16)

38.49 (7.03)

p = 0.309^c

 Glx (L hippocampus)

36.51 (5.25)

36.56 (7.20)

36.59 (5.72)

p = 0.955^c

 Glx (average of R and L)

38.14 (5.61)

38.41 (4.71)

37.57 (5.16)

p = 0.853^c