Schematic representation of the CDKL5 protein and our mutational grouping. Legend: The catalytic region is shown in light grey and the C-terminal region in white. Modified from ‘What We Know and Would Like to Know about CDKL5 and its Involvement in Epileptic Encephalopathy’
. TEY motif Thr-Glu-Tyr motif, NLS
nuclear localisation signals 1 and 2, NES nuclear export signal.