Figure 1
From: There is variability in the attainment of developmental milestones in the CDKL5 disorder
Schematic representation of the CDKL5 protein and our mutational grouping. Legend: The catalytic region is shown in light grey and the C-terminal region in white. Modified from ‘What We Know and Would Like to Know about CDKL5 and its Involvement in Epileptic Encephalopathy’ [17]. TEY motif Thr-Glu-Tyr motif, NLS 1 and NLS 2 nuclear localisation signals 1 and 2, NES nuclear export signal.