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Figure 7 | Journal of Neurodevelopmental Disorders

Figure 7

From: A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis

Figure 7

Microstructural changes in multiple brain regions of mice exposed to 1.0 Gy at E11. (A) Representative anatomical 3D T2-weighted MR images are shown, in combination with the associated diffusion tensor imaging (DTI) scans and corresponding fractional anisotropy (FA) maps. FA values were analysed for both animal groups in the hippocampus (H), thalamus (T), sensory-motor cortex (SMC) and corpus callosum (CC). (B) At 12 weeks of age, DTI scans revealed reduced FA in all regions, except for the SMC. (C) A similar trend was noted at 40 weeks after birth, with significantly decreased FA in the H, SMC and CC. Data are presented as mean ± SEM. *P < 0.05 for comparison with controls. The number of animals used per test is indicated in the graphs (N).

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